Iranian Journal of Diabetes and Obesity IJDO Medical Sciences http://ijdo.ssu.ac.ir 1 admin 2008-6792 2345-2250 8 7 14 8888 13 en jalali 1401 12 1 gregorian 2023 3 1 15 1 online 1 fulltext
en Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A </span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">< 0.05 was considered statistically significant.</span></span><b><span lang="X-NONE" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></b></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (</span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (</span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">> 0.05). HbA1C and LDL levels in the control group increased significantly (</span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">< 0.05). Meanwhile, this group&#39;s HDL levels decreased considerably.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients&#39; serum parameters.</span></span></span></span></span></span><br> &nbsp; Clinical trial, Diabetes mellitus, Blood glucose, HbA1C, HDL, LDL, Ascorbic acid 7 13 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-367&slc_lang=en&sid=1 Shiva Kordestani 0000-0001-7496-3262 No Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Seyyed Behzad Razavi 0000-0003-1298-2868 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mona Najaf Najafi 0000-0003-4962-6787 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Parvin Layegh 0000-0003-4022-9195 No Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammadmobin Miri Moghaddam 0000-0002-2839-8482 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Amirali Aali 0000-0003-2149-5148 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Masoud Mohebbi 0000-0002-2285-6809 Yes Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.