Iranian Journal of Diabetes and Obesity

en Investigating the Levels of Liver Lipogenic and Lipolytic Enzymes in Rat with High-Fat Diet and Sucrose Solution Underwent Progressive Resistance Training تخصصي Special پژوهشي Research Objective: Consuming too much fat or carbohydrates stimulates lipogenesis and excess fat is stored in non-fat tissues, including the liver, and manifests as obesity and fatty liver disease. This study aimed to investigate the effect of eight weeks of progressive resistance training (PRT) on the liver levels of some enzymes affecting lipid metabolism in rats fed a high-fat diet and sucrose solution. Materials and Methods: Twenty-four male wistar rats with 5 weeks of age were randomly divided into two groups: standard diet (SD) (n=8) and high-fat diet and sucrose solution (HFDS) (n=16). Twelve weeks later, HFDS group was divided into two groups: sedentary (HS) and PRT (HPRT). The PRT program was implemented 3 days a week for 8 weeks. Gene expression of AMPKα1, SCD-1, ATGL and FASN enzymes affecting lipid metabolism in liver tissue and its fat content were investigated. Results: HFDS significantly increased the body weight (P: 0.001) and significantly decreased the liver expression of ATGL and FASN (P: 0.001, P: 0.011). Eight weeks of PRT did not show a significant difference in the expression of AMPKα1, SCD-1, ATGL and FASN genes. Rats fed HFDS had considerably higher levels of triglyceride (TG) and total cholesterol (TC) in their liver tissue (P: 0.004, P: 0.001) and PRT did not affect them (P: 0.959, P: 0.809 respectively). Conclusion: It seems that eight weeks of PRT will not change liver lipid metabolism enzymes. Therefore, modifying the diet and changing it, will probably show different results after PRT.   Liver, Enzymes, Exercise, Diet 93 101 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-378&slc_lang=en&sid=1 Reihaneh Delbari 0000-0002-2776-4778 No PhD. Student in Exercise Physiology, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran. Rozita Fathi 0000-0002-4966-2692 Yes Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran. Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran. Alireza Safarzade 0000-0002-8413-3665 No Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran. Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran. Khadijeh Nasiri 0000-0001-9444-9674 No Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran.