en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Overweight and obesity is associated with insulin resistance and is </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">the most important risk factor of type 2 diabetes (T2DM). In present study, we assessed glycemic profile and insulin resistance response to a short term aerobic training in middle-aged men with abdominal obesity.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The subjects included 28 abdominally obese (waist circumference&ge;102cm) middle-aged men (39 &plusmn; 5 year) that were divided into exercise (</span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">n=14</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">) or control (</span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">n=14</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">) groups by randomly. Exercise subject were completed a short-term aerobic training at 55-70 % of maximal heart rate (6 weeks, 3 times / weekly) and control subjects remained no training. Pre-training and post-training of anthropometrical markers, fasting glucose, hemoglobin</span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""> (HbA1C)</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">, insulin and insulin resistance were measured of 2 groups and compared by independent &ndash; paired t test (SPSS, Version 22.0).</span></span><span lang="EN" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Aerobic exercise resulted in a significant decrease in glucose level (114 &plusmn; 13 versus 101 &plusmn; 11 mg/dL, <i>P:</i> 0.009) and HbA1C (6.14 &plusmn; 1.11 versus 4.91 &plusmn; 1.23, <i>P:</i> 0.021) in exercise group. But no significant changes were observed in insulin (8.31 &plusmn; 4.12 versus 8.29 &plusmn; 3.21, <i>P:</i> 0.119) and insulin resistance (2.34 &plusmn; 0.51 versus 2.07 &plusmn; 0.59, <i>P:</i> 0.073) in exercise groups. </span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></span></b><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Based on our finding, </span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">aerobic training independent of insulin function is associated with improved glucose in middle-aged obese men and this improvement can be attributed to other changes caused by exercise that requires further study in this area.</span></span></span> Aerobic exercise, Obesity, Glucose, Insulin function 110 118 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-380&slc_lang=en&sid=1 Reza Naseri Rad 0000-0001-6812-5692 No MS.C, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran. Mojtaba Eizadi 0000-0003-1989-692X Yes Assistant Professor, Department of Exercise Physiology, Faculty of Humanities Sciences, Islamic Azad University, Saveh Branch, Saveh, Iran. Morteza Ghasemi 0000-0002-2142-801X No Assistant Professor, Department of Nursing, Faculty of Medical Sciences, Islamic Azad University, Arak Branch, Arak, Iran.