Iranian Journal of Diabetes and Obesity

en The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men تخصصي Special پژوهشي Research Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM). Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes. Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups. Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.   Corresponding Author: Roghayyeh Afroundeh <a href="https://orcid.org/0000-0002-1592-7330">View Orcid in Profile</a> You can search for this author in <a href="https://pubmed.ncbi.nlm.nih.gov/27055665/">PubMed</a>     <a href="https://scholar.google.com/citations?hl=en&user=EjQS2ysAAAAJ">Google Scholar Profile</a>   Interleukin 6, Salusin-α, Salusin-β, Diabetes, Elderly 129 138 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-382&slc_lang=en&sid=1 Mohammad Ebrahim Bahram 0000-0001-8933-3589 No Ph.D. Students in Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Roghayyeh Afroundeh 0000-0002-1592-7330 Yes Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Mohammad Javad Pourvaghar 0000-0003-0359-525X No Associate Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran. Farnaz Seify Skishahr 0000-0002-4065-379X No Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Leila Katebi 0000-0002-3622-7210 No Assistant Professor, Department of Pediatrics, School of Medicine Bu'ali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran. Ozkan Isik 0000-0003-2561-1695 No Associate Professor, Faculty of sport Sciences, Balikesir University, Balikesir, Turkey