Iranian Journal of Diabetes and Obesity

en The Impact of Resistance and Aerobic Training on the Insulin Synthesis Genes Expression in Diabetic Rats تخصصي Special پژوهشي Research Objective: In the last two decades, genetic studies have strongly supported the effective role of genetic factors on the synthesis of insulin from the pancreas. The purpose of this research is to determine the effect of aerobic and resistance exercises on the expression of NeruoD1 and PDX1 in pancreatic tissue, as well as serum insulin and glucose levels in type 2 diabetic rats. Materials and Methods: 21 male wistar rats (220±10 g) were included. Then diabetic rats were randomly assigned into 3 groups: 1) control (no-training), 2) resistance training and 3) aerobic training. Exercise training lasted 10 weeks and 5 times weekly for training groups. After intervention, NeruoD1 and PDX1 expression in pancreas, insulin and glucose were compared between groups. Data compared by one way ANOVA and Tukey's post hoc test between groups (P < 0.05). Results: Compared to control rats, resistance and aerobic training led to significant increase in serum insulin (P: 0.001, P: 0.013 respectively), PDX1 expression (P: 0.001, P: 0.001 respectively) and decrease glucose (P: 0.001, P: 0.001 respectively). Significant difference was not observed between control and aerobic groups with regard to NeruoD1 expression (P: 0.077). In addition, NeruoD1 expression in resistance group was significantly higher than aerobic and control groups (P: 0.018, P: 0.001, respectively). Conclusion: Despite the improvement of insulin and glucose in response to both aerobic and resistance training, it seems that resistance training affects genes affecting insulin synthesis and transcription more than aerobic training.   Insulin synthesis, Aerobic and resistance training, Type 2 diabetes, Gene’s expression 190 193 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-389&slc_lang=en&sid=1 Mohammad Hossein Ghofrani 0000-0002-2152-1791 No PHD Candidate of Exercise Physiology, Department of Physical Education and Sport Sciences Karaj Branch, Islamic Azad University, Karaj, Iran. Alireza Rahimi 0000-0002-9971-7380 Yes Associate professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran. Eidi Alijani 0000-0002-9862-1096 No Full professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran. Foad Feizolahi 0000-0003-1847-9745 No Assistant professor of Exercise physiology,Department of Physical Education and sport Science, Karaj Branch, Islamic Azad University, Karaj. Iran.