Iranian Journal of Diabetes and Obesity

en Clinical Manifestations and Outcomes of COVID-19 in Diabetes Mellitus People, Yazd, Iran-2021 تخصصي Special پژوهشي Research Objective: Diabetes mellitus is reported to be the third most prevalent comorbidity with COVID-19, after cardio‐cerebrovascular disease and hypertension. Furthermore, diabetes increases the likelihood of admission to the hospital and intensive care unit and death from COVID-19. The aim of the present study was to compare the clinical manifestations and outcomes of COVID-19 in diabetic versus non-diabetic inpatients. Materials and Methods: The medical records of 6525 patients with definitive diagnosis of COVID-19 were obtained from the reference COVID-19 diagnosis laboratory from January to July 2021 in Yazd, Iran. Patients were investigated for data on onset, clinical history, and fatality rate. COVID-19-related death was defined as positive RT-PCR in at least one of three nasal samples. Data were analysed using SPSS 24. Results: Among inpatients, 21.2% were diabetic. The mean ages of diabetic and non-diabetic patients were 64.45 (±13.87) and 52.98 (±20.36) years, respectively. Diabetics were more likely to be admitted to the intensive care unit (6.8% vs. 5%, P= 0.02) and the fatality rate was higher among them than non-diabetics (22.6% vs. 12%, P< 0.001). In diabetics, the mean age of non-survivors was lower than that of survivors (62.57 vs. 70.48, P= 0.0001) and the frequency of death was higher among men than women (53% vs. 47.5%, P= 0.045). Generally, diabetes has the strongest association with COVID-19 death (P= 0.0001). Conclusion: Diabetic patients experience more adverse outcomes because of COVID-19. These findings indicate the need for special attention in relation to prevention treatment against COVID-19 in patients with diabetes.   COVID-19, Diabetes, Inpatients, Outcomes 194 200 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-391&slc_lang=en&sid=1 Akram Mehrabbeik 0000-0002-7088-3545 No Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd. Iran. Mohsen Mirzaei 0000-0002-4153-5023 No Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Maryam Askari 0000-0002-8422-8293 No Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohamad Ali Sahami 0000-0002-1639-904X No Yazd Health Network, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mozhgan Minoosepehr 0000-0003-0450-5914 No Health Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nasim Namiranian 0000-0002-5133-6204 Yes Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd. Iran.