en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.</span></span></span></span></span></span><br> &nbsp; Gamma-glutamyl transferase, Type 2 diabetes mellitus, Body mass index 243 255 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-396&slc_lang=en&sid=1 Sachini M Thennakoon 0000-0002-9872-4650 Yes Department of Biomedical Sciences, Faculty of Science, NSBM Green University, Mahenwatta, Pitipana, Homagama (10206), Sri Lanka Niroshima D Withanage 0000-0002-4602-5006 No Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.