Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
1
admin
2008-6792
2345-2250
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8888
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jalali
1402
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gregorian
2024
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online
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fulltext
en
Evaluation of Anemia Effect on HbA1c Level Measurement in Type 2 Diabetic People
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">For many years HbA1c used as diagnostic criteria for diabetes<b>, </b>however, measurement of HbA1 has some limitations that cannot be accurately assess blood glucose levels in conditions such as changes in red blood cell life. in this study, we evaluated and compared the levels of HbA1C in diabetic, pre-diabetic and non-diabetic individuals to understand the role and relationship of different values of RBC`s indices in these conditions.</span></span><i><span dir="RTL" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Materials and Methods</span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">This study performed<u> </u>between august to December of year 2021, and the demographic information and hematologic indices of 706 individuals which referred to laboratories in Gorgan city were investigated. According to results of FBS and HbA1c, individuals categorized in three distinct healthy (H), pre-diabetic (PD), and diabetic (D) groups base on latest ADA criteria.</span></span><i><span dir="RTL" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Results</span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (<i>P</i>= 0.045).</span></span><span lang="EN-GB" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Conclusion</span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">In this study, it was shown that changes in RBC indices in anemia can lead to inaccurate measurement of HbA1c level.</span></span><i><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></span></span></span></span><br>
HbA1c, Diabetes, RBC indices, Hemoglobinopathies, Anemia
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http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-403&slc_lang=en&sid=1
Samira
Kashani