en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Objective</span></span></span></b><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The purpose of this experimental research is to investigate the effects of High-Intensity Interval Training (HIIT) and Lipoic Acid </span></span></span><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">)</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">ALA</span></span></span><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">(</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> supplementation on VEGFR-3 of pancreatic in diabetic Wistar rats model.</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Materials and Methods</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">20 male Wistar rats weighing 159 &plusmn; 3 gr and aged3 weeks, were randomly assigned into 4 groups:1) diabetes/sham, 2)diabetes/ ALA, 3)diabetes/exercise/sham, and 4) diabetes /exercise/ ALA. Diabetes was induced with streptozotocin (65 mg/kg dose) and Nicotinamide (120 mg/kg dose). After two weeks of familiarization with interval training, the rats started their main training, included 10 repetitions of 4 minutes of running on the treadmill with an intensity of 85-90% VO2max and 2 minutes of active rest between repetitions (5-10 m/min) for 5 sessions per week for 6 weeks</span></span></span><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">.</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> ALA supplement was taken at a dose of 20 mg/kg/day for 6 weeks. One-way ANOVA test used and Tukey&#39;s post hoc test at for analysis (<i>P</i>&le; 0.05).</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Results</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">HIIT has a significant effect on blood glucose (<i>P</i>= 0.004) and insulin (<i>P</i>= 0.001) and VEGFR3 (<i>P</i>= 0.001) of pancreatic tissue of diabetic rats.</span></span></span><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Lymphatic vessels play an important role in the pancreas and treat diabetes</span></span></span><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">.</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The results of this research showed that HIIT and ALA increased lymphangiogenesis in the diabetic rat model.</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> &nbsp; ALA, HIIT, Lymph angiogenesis, Diabetic model rats 103 111 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-412&slc_lang=en&sid=1 Seyed Ramin Hashemian Esfahani 0000-0002-6676-9627 No Department of Physical Education, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran. Minoo Dadban Shahamat 0000-0003-2811-9874 Yes Department of Physical Education, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran. Asra Askari 0000-0002-4948-9658 No Department of Physical Education, Gorgan Branch, Islamic Azad University, Gorgan, Iran. Abbas Nezhadebrahimi 0000-0002-8181-7826 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.