en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Objective</span></span></span></b><b><span lang="EN" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The role of inflammation in the pathophysiology of obesity is significant, as a known connection between metabolism and immune function. Lifestyle modification may be a useful strategy to prevent obesity-related complications. To the best of our understanding, there have been no studies conducted to examine the impact of various exercise protocols on the profile of inflammatory factors within the body. The objective of this study was to examine the impact of high-intensity functional training (HIFT) on the levels of semaphorin-3E (Sema-3E) in individuals who are obese.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Materials and Methods</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">This study examined the effects of a 12-week HIFT program on 22 obese men aged 23 to 32 years old. Participants were divided into two groups: a control group (C) and a HIFT exercise group (H). Body mass index (BMI) and blood levels of Sema-3E were measured before and after the intervention period.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Results</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">In this study, the results of the ANOVA analysis showed a significant difference of the levels of semaphorin-3E between the studied groups (<i>P</i>< 0.001).</span></span></span></span></span></span></span><br> <b><span lang="EN" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The results of the present study show that HIFT reduced the levels of semaphorin-3E in the body and may be effective in reducing systemic inflammation.</span></span></span> Obesity, High intensity functional training, Sema-3E, Inflammation 48 53 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-438&slc_lang=en&sid=1 Heidar Ebadi Asl No PhD student, Department of Exercise Physiology, University of Guilan, Guilan, Iran. Bahman Mirzaei 0000-0003-3723-7434 Yes PhD, Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Guilan, Iran. Arsalan Damirchi No PhD, Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Guilan, Iran.