en عمومى General پژوهشي Research Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. Materials and Methods: All rats of control and treatment groups received daily tap water (P.O) as vehicle mixed with fructose 10%. Two treatment groups received FAF oleo-gum resin at doses of 25 or 50 mg/kg (P.O). Normal rats received only tap water and standard chow food. Body weights, abdominal fat, size of epididymal adipocyte and serum leptin were recorded. Result: Administration of Ferula asafoetida significantly decreased body weights, abdominal fat and size of epididymal adipocyte compared to untreated rats (P<0.05). Levels of serum leptin were significantly decreased in treated rats (P<0.05). Conclusion: This study showed that Ferula asafoetida extract has anti-obesity, fat lowering effects and can prevent liver steatosis in type 2 diabetic rats. Reduction of serum leptin is associated with protective effects of Ferula asafoetida in obese diabetic rats. Ferula asafoetida, Diabetes mellitus, Obesity, Adipocyte, Liver, Rat, 120 126 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-23&slc_lang=en&sid=1 Hossain Azizian No Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran Mohammad Ebrahim Rezvani Yes Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran Mansour Esmaeilidehaj No Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran Seyyed Majid Bagheri No Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran