en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The global rise of obesity has increased the prevalence of type 2 diabetes mellitus (T2DM) and the risk of Alzheimer&rsquo;s disease (AD). The obesity, a key risk factor of T2DM, leads to insulin resistance, which contributes to cognitive decline and potentially AD through shared metabolic pathways. This Commentary highlights the connection between obesity, T2DM, and AD, suggesting that lifestyle changes like weight loss and discontinuation of sugar consumption may help to prevent these conditions. Comprehensive public health strategies focusing on diet, exercise, and education are essential to reduce the growing health crisis and improve metabolic and cognitive health globally.</span></span></span></span></span></span></span><br> &nbsp; Obesity, Type 2 diabetes mellitus, Type 3 diabetes, Alzheimer's disease, Epidemic 76 78 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-442&slc_lang=en&sid=1 Roya Rafaiee 0000-0003-0889-710X No MD, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Seyedeh Maryam Mousavi Bourkheili 0009-0006-5868-8612 No MSc, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Raheleh Rafaiee 0000-0003-2796-5868 Yes MD, Ph.D., Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.