Iranian Journal of Diabetes and Obesity

en Assessing the Association between Anti-Diabetic Medication Adherence and Glycemic Control in Type 2 Diabetes تخصصي Special پژوهشي Research Objective: Adherence to anti-diabetic medications in diabetic patients plays a considerable role in glycemic control, prevention of short-term and long-term morbidities, and diabetes-related mortality. The current study aims to evaluate the factors associated with adherence to medications among patients with type 2 diabetes. Materials and Methods: The current study was conducted on 366 diabetic patients who were referred to the Institute of Endocrinology and Metabolism. The HbA1C was measured at baseline and then after six months. The validated questionnaire on adherence to refills and medication scale (ARMS) was filled, and factors associated with medication adherence were assessed. The higher ARMS scores represented poorer adherence to the medication. Results: Diabetic patients with adherence to anti-diabetic agents represented significantly lower levels of HbA1C both at baseline (P< 0.001) and the six-month follow-up (P< 0.001) compared to the non-adherent group. In the correlation analyses, the ARMS score was significantly correlated with the A1C levels measured at the baseline (rs= 0.37, P< 0.001) and after 6 months (rs= 0.40, P< 0.001) as well as the duration of diabetes (rs= 0.16, P= 0.003). The subsequent logistic regression analysis highlighted the use of insulin as the main determinant of adherence to medications (OR: 0.59; 95%CI: 0.35-0.99), after controlling for age, gender, diabetes duration and number of medications. Conclusion: The current study revealed that adherence to the anti-diabetic medication is associated with remarkably improved glycemic control. Diabetes duration and insulin use were inversely correlated with adherence to medication, while there was no association with age, gender, numbers of drugs. Type 2 diabetes, Medication adherence, Glycemic control 79 87 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-443&slc_lang=en&sid=1 Aida Vatan Meidanshahi 0000-0002-7695-5546 No Endocrine Research Center; Institute of Endocrinology and Metabolism; Iran University of Medical Sciences (IUMS); Tehran; Iran. Fariba Alaei-Shahmiri 0000-0003-3220-8618 No Endocrine Research Center; Institute of Endocrinology and Metabolism; Iran University of Medical Sciences (IUMS); Tehran; Iran. Fatemeh Golgiri 0000-0003-4855-1744 No Endocrine Research Center; Institute of Endocrinology and Metabolism; Iran University of Medical Sciences (IUMS); Tehran; Iran. Mohammad Ali Mavvaji 0000-0002-7158-9399 No Otorhinolaryngology Head and Neck Department, Otorhinolaryngology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Bentolhoda Dinko 0009-0001-4569-9850 No Endocrine Research Center; Institute of Endocrinology and Metabolism; Iran University of Medical Sciences (IUMS); Tehran; Iran. Raziyah Shahi 0000-0002-1271-1235 No Iran University of Medical Sciences (IUMS); Tehran; Iran. Sedighe Moradi 0000-0002-1840-6186 Yes Endocrine Research Center; Institute of Endocrinology and Metabolism; Iran University of Medical Sciences (IUMS); Tehran; Iran.