Iranian Journal of Diabetes and Obesity

en Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Consumption of Cinnamon on Meteorin-like protein (METRNL) and Irisin in Diabetic Women تخصصي Special پژوهشي Research Objective: Studies show that exercise and herbal supplements help improves type 2 diabetes. The aim of this study was to investigate the effect of different intensities aerobic exercise with resistance training and cinnamon on the levels of METRNL and irisin in diabetic women. Materials and Methods: In this clinical trial study, 54 diabetic women (age 41.73± 4.05) were selected from Nowshahr and randomly allocated into six groups; Control (C), Resistance and Moderate Aerobic Exercise (RME, 50% VO2max, 200 kcal), Resistance and Vigorous Aerobic Exercise (RVE, 80% VO2max, 200 kcal), Cinnamon (Ci, 1000 mg/day), Resistance and Moderate Aerobic Exercise+Cinnamon (RMECi), Resistance and Vigorous Aerobic Exercise+Cinnamon (RVECi). Data were analyzed using an independent t-test and ANCOVA (P< 0.05). Results: It was observed a significant increase in Metrnl, irisin in the RME (P= 0.041 and P= 0.004, respectively), RVE (P= 0.0001 and P= 0.0001, respectively), Ci (P= 0.006 and P= 0.0001, respectively), RMECi (P= 0.00 and P= 0.0001, respectively) and RVECi (P= 0.001 and P= 0.0001, respectively) compared to group C. The increase in Metrnl and irisin was significant in RVE compared to RME (P= 0.045, and P= 0.028, respectively); RMECi relative to RME (P= 0.004) and Ci (P= 0.0001); RVECi compared to RME (P= 0.0001), RVE and Ci (P= 0.0001). It was also observed a significant decrease in HOMA-IR in the RME (P= 0.014), RVE (P= 0.001), Ci (P= 0.044), RMECi (P= 0.0001), and RVECi (P= 0.0001) compared to group C. Conclusion: Combining exercise with cinnamon may help prevent or delay T2D complications. RVE exercise showed greater improvements in irisin and HOMA-IR than RME.   Cinnamomum, Diabetes mellitus, Exercise, FNDC5 protein, Irisin, Metrnl protein 119 129 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-447&slc_lang=en&sid=1 Mahdieh Ghasemi 0000-0003-3273-0772 No Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. Ahmad Abdi 0000-0002-7734-7518 Yes Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. Alireza Barari 0000-0001-5199-463X No Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. Khosrow Jalali Dehkordi 0000-0003-0210-5984 No Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.