Iranian Journal of Diabetes and Obesity

en BCL2 Expression in the Brains of Diabetic Rats Treated with Ginger تخصصي Special پژوهشي Research Objective: Diabetes is one of the most common high-risk diseases which causes many side effects in most body systems such as the nervous system. The medicinal plants, has been suggested to reduce the side effects of this diseases. In this experimental study, we examined the effect of ginger on BCL2 gene expression in the hippocampus of diabetic rats. Materials and Methods: In this experimental study, we used 60 Wistar rats (200gr). We separated the rats into one healthy group and four groups of diabetics which after seven days of diabetes induction via Streptozotocin (60 mg/kg), received different mixture of insulin and ginger for 6 weeks. 24 hours after the last injection, brains of rats were removed and the hippocampus region was studied histologically and the BCL2 gene expression examined by Real-time PCR. Results: According to the results, <a name="_Hlk23279101">the blood glucose level in the ginger treated group (183.17) decreased significantly compared to the diabetic control group</a> (232.5) (P˂ 0.01). In the expression of BCL2 gene, there was not any significant difference among the groups. In the histological examination of the hippocampus CA1 region, the ginger-insulin treated group had less pyknotic neurons than the diabetic control group. Conclusion: According to results, the ginger, in addition to glycaemia reduction and despite any significant change in BCL2 gene expression, can cause the safe neurons with the bright nucleus and clear nucleolus remain in the treated group, which can indicate that maybe ginger could inhibit the creation of apoptosis.   Apoptosis, Glycaemia, Ginger, Hippocampus 159 165 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-451&slc_lang=en&sid=1 Mohammad Mohsen Taghavi 0000-0003-3247-5484 No Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Seyed Hassan Eftekhar-Vaghefi 0000-0002-5083-9563 No Department of Anatomy, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Zahra Taghipour 0000-0002-2305-4912 No Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ahmad Shabanizadeh 0000-0002-6510-1190 No Department of Anatomical Sciences, Medical School, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Abdolreza Babaee 0000-0002-9848-5442 No Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ilia Najmadini 0009-0003-4654-1291 No Student in medical science, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Akram Molahosseini 0000-0002-2011-334X Yes Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.