Volume 11, Issue 3 (volume 11, number 3 2019)                   IJDO 2019, 11(3): 181-187 | Back to browse issues page

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Ghaedi H. Perlipin a Protein of Subcutaneous Adipose Tissue and Pancreatic Bcells Function in Diabetic Rats. IJDO. 2019; 11 (3) :181-187
URL: http://ijdo.ssu.ac.ir/article-1-512-en.html
Assistant Professor in Exercise Physiology, Lamerd Branch, Islamic Azad University, Lamerd, Iran.
Abstract:   (149 Views)
Objective: The aim of this study was to compare the three endurance training intensities on the expression of Perlipin A protein in subcutaneous adipose tissue and pancreatic B-cells function in male diabetic rats.
Materials and Methods: In this study, 40 healthy male wistar rats were divided into five groups, including diabetic with low intensity endurance training, diabetic with moderate intensity endurance training, diabetic with high intensity endurance training, diabetic control and healthy control. After diabetic induction with streptozotocin, endurance training was performed with low intensity, moderate and severe for eight weeks, three sessions per week. The relative expression of Perilipin A was measured by western blot technique.
Results: The results indicated a significant effect of endurance training with three intensities on serum levels of insulin and glucose and pancreatic B-cells function (P-value: 0.001). Also the results showed that there was no significant difference between Perlipin A expression in healthy and diabetic control groups with endurance training groups (with low, moderate and high intensity) (P-value: 0.07).
Conclusion: However, Moderate and high intensity endurance training compared to low-intensity training can compensate for the loss caused by diabetes in the expression of the Perlipin A protein but the difference was not significant. It seems that more intensity endurance training lead to more increase in Perlipin A expression in diabetic rats.
Full-Text [PDF 290 kb]   (43 Downloads)    
Type of Study: Research | Subject: Special
Received: 2020/02/15 | Accepted: 2020/02/15 | Published: 2020/02/15

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