Volume 11, Issue 4 (volume 11, number4 2019)                   IJDO 2019, 11(4): 257-264 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ramezani J, Azarbayjani , M A, Peeri M. The Aerobic Training and Berberine Chloride Intervention on Pancreatic Tissue Antioxidant Enzymes and Lipid Peroxidation in Type 1 Diabetic Rats. IJDO. 2019; 11 (4) :257-264
URL: http://ijdo.ssu.ac.ir/article-1-536-en.html
Professor Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (1258 Views)
Objective: Aerobic training and berberine chloride include antioxidant characteristics. In this study, aerobic training and berberine chloride intervention on the activity of antioxidant enzymes and lipid peroxidation of pancreatic tissue were investigated in type 1 diabetic male wistar rats.
Materials and Methods: In the current study, 56 Wistar male rats were randomly assigned to seven different groups (n= 8), these groups include healthy control, diabetic control, Berberine-treated diabetes (15&30 mg/kg), aerobic training-treated diabetes, Diabetes treated with Berberine and aerobic training (15&30 mg/kg). The aerobic training schedule consisted of 6 weeks treadmills with a frequency of 5 sessions per week. The Berberine was also fed a specific dose every day and a half before training. The superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were assessed using ELISA method.
Results: The results showed that aerobic training, as well as the intervention of Aerobic Training and Berberine chloride, had a significant effect on the increase of antioxidant enzymes SOD and CAT in the pancreatic tissue groups (P-value< 0.05), but did not significantly affect the GPX level (P-value> 0.05). There was a significant decrease in MDA level in all treatment groups (P-value< 0.05). In diabetic groups that received both treatments at the same time, the MDA level more decreased (P-value< 0.0005).
Conclusion: The aerobic training and berberine chloride concurrent intervention have a greater effect on the antioxidant enzymes in the pancreatic tissue of diabetic specimens. Therefore, it is recommended that aerobic training be done with berberine chloride.
Full-Text [PDF 457 kb]   (311 Downloads)    
Type of Study: Research | Subject: Special
Received: 2020/05/21 | Accepted: 2020/05/21 | Published: 2020/05/21

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Iranian Journal of Diabetes and Obesity

Designed & Developed by : Yektaweb