Volume 12, Issue 1 (volume 12, number 1 2020)                   IJDO 2020, 12(1): 14-21 | Back to browse issues page


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Shokrolahi Ardakani A, Abednatanzi H, Gholami M, Shakeri N. The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats. IJDO. 2020; 12 (1) :14-21
URL: http://ijdo.ssu.ac.ir/article-1-544-en.html
PhD, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (474 Views)
Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats.
Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups.
Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001).
Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.
Full-Text [PDF 131 kb]   (84 Downloads)    
Type of Study: Research | Subject: Special
Received: 2020/07/2 | Accepted: 2020/07/2 | Published: 2020/07/2

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