Volume 13, Issue 1 (3-2021)                   IJDO 2021, 13(1): 40-47 | Back to browse issues page


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Ahmadi Nasab G, Delavar R, Taheri H. The Effect of Combined Exercise Course and Aloe-Vera Supplementation on Renal Function and Lipid Profile in Type 2 Diabetes Mellitus Patients: A Randomized Clinical Trial. IJDO 2021; 13 (1) :40-47
URL: http://ijdo.ssu.ac.ir/article-1-610-en.html
Assistant Professor, Department of Sport Sciences, Education and Psychology Faculty, University of Sistan and Baluchestan, Zahedan, Iran
Abstract:   (1392 Views)
Objective: Renal failure is a complication of diabetes. It can be the risk factor of cardiovascular disease. This study aimed to evaluate the effect of exercise course and Aloe-Vera supplementation on renal function and lipid profile in type 2 diabetes mellitus (T2DM) patients.
Materials and Methods: This is a clinical trial double blind with pre-test and post hoc test analyses with a control group. The studied population included a group of T2DM diagnosed patients among whom 24 men (40-60years) were selected voluntarily and purposefully and were classified into three groups by balanced block randomization method, exercise(E), exercise + supplement (E+S), and control (C), (n=8/group). Combined exercise was planned in two 12-minute repetitive sets with 70% 1RM. Then the participants ran for two 10- minute sets with 70-75% maximum heart rate intensity on treadmill. E+S participants consumed 500 mg/day Aloe Vera for 6 weeks. Obtained data by SPSS-19 software were analyzed using co-variance analysis method with Bonferroni post hoc test (P-value<0/05).
Results: Results showed that E and E+S significantly improved GFR (P-value=0.011) and E with or without Aloe-Vera consumption decreased creatinine levels (P-value=0.042) and increased HDL levels (P-value˂0.001). The results demonstrated that LDL and TG levels showed no significant difference in reaction to the combined exercise and supplementation.
Conclusion: Combined exercise along with Aloe-Vera supplementation has had significant effect on improving renal factors and lipid profile of T2DM diagnosed patients
Full-Text [PDF 155 kb]   (453 Downloads)    
Type of Study: Research | Subject: Special
Received: 2021/03/13 | Accepted: 2021/03/20 | Published: 2021/03/20

References
1. Zhang Y, Wu X, Shuai T, Wu C, Shen J, Zhong G. Effect of Konjac Glucomannan on Hyperuricemic Rats.Research & Reviews: Journal of Food and Dairy Technology. 2016;4(2):8-15.
2. Jarvisalo MJ, Putto-Laurila A, Jartti L, Lehtimaki T, Solakivi T, Ronnemaa T,et al. Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes. 2002;51(2):493-8. [DOI:10.2337/diabetes.51.2.493]
3. Bonakdaran S, Armanpour P. Evaluation of risk factors of renal involvement in patients with type 2 diabetes. Journal of Mashhad University of Medical Sciences. 2016;59(4):211-24.(in Persian)
4. Hosseini M, Bagheri Afsariehee MR. The effect of high intensity interval training and aloe Vera consumption on resistin and insulin resistance index in diabetic rat. Feyz Journal of Kashan University of Medical Sciences. 2018;22(4):370-8.(in Persian)
5. Eatemady Boroujeni A, Kargarfard M, Mojtahedi H, Rouzbehani R, Dastbarhagh H. Comparison of the effects of 8-weeks aerobic training and resistance training on lipid profile in patients with diabetes type 2. Journal Of Isfahan Medical School. 2014; 32(282):524-533.(in Persian)
6. Rahimi N, Marandi SM, Kargarfard M. The effect of Eight Weeks Aquatic Training on Lipid Profile of Patients who Suffer from Type II Diabetes. Journal of Isfahan Medical School. 2011;29(148).(in Persian)
7. Li XH, Lin HY, Wang SH, Guan LY, Wang YB. Association of microalbuminuria with metabolic syndrome among aged population. BioMed research international. 2016;2016. [DOI:10.1155/2016/9241278]
8. Mehrabani G, Rezaei R, Karimi M, Amini M. The effect of aerobic exercise on renal function and metabolic syndrome in kidney transplant athletes. Journal of Fasa University of Medical Sciences. 2017;7(2):172-80.(in Persian)
9. Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. Journal of ethnopharmacology. 1999;68(1-3):3-7. [DOI:10.1016/S0378-8741(99)00085-9]
10. Tarik Abdulqadir Abdal ARH, Melen Mansour Markus. Effects of aloe vera extracted on liver and kidney function changes induced by hydrogen peroxide in rats. International Journal of Research in Medical Sciences. 2020;8(1):102-8. [DOI:10.18203/2320-6012.ijrms20195891]
11. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clinical and Experimental Pharmacology and Physiology. 2006;33(3):232-7. [DOI:10.1111/j.1440-1681.2006.04351.x]
12. Saka WA, Akhigbe RE, Popoola OT, Oyekunle OS. Changes in serum electrolytes, urea, and creatinine in Aloe vera-treated rats. Journal of Young Pharmacists. 2012;4(2):78-81. [DOI:10.4103/0975-1483.96620]
13. Hosseini A, Khoshsovt F, Ahmadi M, Azarbayjani MA, Salehi O, Farkhaie F. Effects of aloe vera and swimming training on lipid profile of streptozotocin induced diabetic rats. Nutrition and food sciences research. 2020;7(1):9-16. [DOI:10.29252/nfsr.7.1.9]
14. Mogharnasi M, Arabi SR, Mohammadnia Ahmadi M. The Effect of Short-Term Colostrum Supplementation on Serum Levels of Malondialdehyde and Total Antioxidant Capacity Due to Acute Resistance Exercise Training in Healthy Men. Armaghane danesh. 2019 Dec 10;24(5):906-21.(in Persian)
15. Mokhtari F, Esfarjani F, Kargar Fard M. The effect of combined aerobic exercise and barley β-glucan on lipid profile and glucose blood of women with diabet type two. iranian journal of diabetes and metabolism. 2014;13(4):340-51.(in Persian)
16. Alinejad Mofrad S, Foadoddini M, Saadat Joo AR. Eeffect of Aloe Vera extract on blood lipids in patients with pre-diabetes: A randomized double-blind clinical trial. Journal of Health Promotion Management. 2015;4(4):53-63.(in Persian)
17. Khajehlandi A, Abed Natanzi H, Nikbakht H. The effect of swimming and aloe vera extract on serum of visfatin levels, and the ratio of triglycerides to high-density lipoproteins and glucose in streptozotocin-induced diabetic male rats.Journal of Arak University of Medical Sciences. 2017;20(3):39-47.(in Persian)
18. Ayoubi A, Omidi A, Valizade R, Mousaei A. Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats. Journal of Birjand University of Medical Sciences. 2013;20(02):144-152.(in Persian)
19. Ngala RA, Osei S, Gmegna PR. Effect of exercise on lipid profile and oxidative stress in patients with type 2 diabetes mellitus. American Journal of Drug Discovery and Development. 2013;3(1):23-31. [DOI:10.3923/ajdd.2013.23.31]
20. Mohammad Rahimi G, Attarzadeh Hosseini. The effect of aerobic training and diet on lipid profile and liver enzymes in obese women with type II diabetes.2020;21(5):41-50.(in Persian)
21. Kamal-Eldin A, Moazzami A. Plant sterols and stanols as cholesterol-lowering ingredients in functional foods. Recent Patents on Food, Nutrition & Agriculture. 2009;1(1):1-4.(in Persian) [DOI:10.2174/2212798410901010001]
22. Ranallo RF, Rhodes EC. Lipid metabolism during exercise. Sports Medicine. 1998;26(1):29-42. [DOI:10.2165/00007256-199826010-00003]
23. Seiavoshy H, Samavatisharif M, Keshvari M, Ahmadvand A. The effect of resistance training programs on GFR and some biochemical factors of renal function in elderly males with type 2 diabetes. Sadra Medical Journal. 2015;3(1):31-42.(in Persian).
24. Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, et al. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015;38(1):126-31. [DOI:10.2337/dc14-1742]
25. Zhang X, Chen C. A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy. Endocrine. 2012 Jun;41(3):398-409. [DOI:10.1007/s12020-012-9623-1]
26. Sarkar D, Dutta A, Das M, Sarkar K, Mandal C, Chatterjee M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian journal of pharmacology. 2005;37(6):371. [DOI:10.4103/0253-7613.19073]
27. Gailiūnienė A, Stasiulis A, Michailovienė J. The effect of submaximal exercise on blood creatinine, urea, total protein and uric acid levels of trained and untrained subjects. Baltic Journal of Sport and Health Sciences. 2007;3(66). [DOI:10.33607/bjshs.v3i66.542]
28. Loots DT, van der Westhuizen FH, Botes L. Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits. Journal of agricultural and food chemistry. 2007;55(17):6891-6. [DOI:10.1021/jf071110t]
29. Saritha V, Anilakumar KR, Khanum F. Antioxidant and antibacterial activity of Aloe vera gel extracts. International Journal of Pharmaceutical & Biological. Archives. 2010;1(4):376-84.
30. Gaeini A, Hoseini A, Samadi A. The comparison of two soccer and semi-soccer protocol induced excretion of urinary protein in adolescent male soccer players. Metabolism and Exercise. 2011;1(2):99-106.(in Persian)
31. Gorriz JL, Martinez-Castelao A. Proteinuria: detection and role in native renal disease progression. Transplantation reviews. 2012;26(1):3-13. [DOI:10.1016/j.trre.2011.10.002]

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