Comparison of the Agouti Dependent Protein and Neuropeptide Y Response to the High Intensity Interval Training in Obese and Underweight Men

Akbarpour Beni, Mohsen; Fathollahi Shoorabeh, Fazlollah; Mardanian, Mohammad Reza; Samari Ebrahimzadeh, Zahra

doi:10.18502/ijdo.v13i2.6478

Volume 13, Issue 2 (volume 13, number 2 2021) IJDO 2021, 13(2): 95-101 | Back to browse issues page

‎ 10.18502/ijdo.v13i2.6478

Mendeley

Zotero

RefWorks

Akbarpour Beni M, Fathollahi Shoorabeh F, Mardanian M R, Samari Ebrahimzadeh Z. Comparison of the Agouti Dependent Protein and Neuropeptide Y Response to the High Intensity Interval Training in Obese and Underweight Men. IJDO 2021; 13 (2) :95-101
URL: http://ijdo.ssu.ac.ir/article-1-631-en.html

Comparison of the Agouti Dependent Protein and Neuropeptide Y Response to the High Intensity Interval Training in Obese and Underweight Men

Mohsen Akbarpour Beni

, Fazlollah Fathollahi Shoorabeh ^*

, Mohammad Reza Mardanian

, Zahra Samari Ebrahimzadeh

Expert Sports Sciences, University of Qom, Qom, Iran.

Abstract: (1167 Views)

Objective: Appetite regulation has a great impact on energy homeostasis. This study aimed to compare the response agouti-related protein (AGRP) and neuropeptide Y (NPY) to a single high intensity interval training (HIIT) in obese and underweight men.
Materials and Methods: This semi-experimental research conducted on 40 obese and underweight men who were divided into four groups including experimental groups (10 obese, and 10 underweight men) and control groups (10 obese, and 10 underweight controls). Both groups were evaluated by biochemical measurements in two stages of pre-test and post-test. HIIT was carried out to the experimental groups during one session. Data were analyzed using one-way ANOVA and T-test using SPSS 21 software.
Results: NPY levels showed a significant difference in pre and post-test in both experimental groups, NPY increased 6.14% in obese men and 25.50% in underweight men, which was significant in both obese (P-value= 0.002) and underweight (P-value= 0.007) groups. In addition, AGRP levels increased 1.91% in obese men and 6.65% in underweight men, although this was not significant (P-value= 0.098). However, no significant differences were observed among groups in the levels of NPY and AGRP (P-value= 0.114).
Conclusion: The results of the present study showed that HIIT can increase the amount of AGRP and NPY in obese and underweight men. Therefore, appetite neuropeptides increase after a training session, which should be considered in the balance of energy and food intake after exercise.

Keywords: Agouti dependent protein, Neuropeptide Y response, High intensity interval training, Obesity

Full-Text [PDF 557 kb] (574 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/06/16 | Accepted: 2021/06/20 | Published: 2021/06/20

References

1. Roux L, Donaldson C. Economics and obesity: costing the problem or evaluating solutions?. Obesity research. 2004;12(2):173-9. [DOI:10.1038/oby.2004.23]

2. Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. The Journal of Clinical Endocrinology & Metabolism. 2010;95(4):1609-16. [DOI:10.1210/jc.2009-2082]

3. Schneeberger M, Gomis R, Claret M. Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. Journal of endocrinology. 2014;220(2):T25-46. [DOI:10.1530/JOE-13-0398]

4. Hillebrand JJ, De Wied D, Adan RA. Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides. 2002;23(12):2283-306. [DOI:10.1016/S0196-9781(02)00269-3]

5. Loos RJ, Rankinen T, Rice T, Rao DC, Leon AS, Skinner JS, et al. Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. The American journal of clinical nutrition. 2005;82(5):1097-101. [DOI:10.1093/ajcn/82.5.1097]

6. Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, et al. α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. Journal of Neuroscience. 2000;20(4):1550-8. [DOI:10.1523/JNEUROSCI.20-04-01550.2000]

7. Hamedinia M, Davarzani Z, Hosseini KA. The Effect of one Session of Swimming and Running Training on Hunger Rate and Ghrelin, Insulin and Cortisol Hormones of the Plasma in the Healthy Girls. 2011;13(1):82-9. (in Persian)

8. ZilaeiBouri S, Khedri A, ZilaeiBouri M. Comparing the effects of aerobic exercises of high and moderate intensity on serum leptin levels and capacity of fat oxidation among young obese girls. Journal of Fasa University of Medical Sciences. 2013;3(1):81-7. (in Persian)

9. Cheng MH, Bushnell D, Cannon DT, Kern M. Appetite regulation via exercise prior or subsequent to high-fat meal consumption. Appetite. 2009;52(1):193-8. [DOI:10.1016/j.appet.2008.09.015]

10. Ghanbari-Niaki A, Nabatchian S, Hedayati M. Plasma agouti-related protein (AGRP), growth hormone, insulin responses to a single circuit-resistance exercise in male college students. Peptides. 2007;28(5):1035-9. [DOI:10.1016/j.peptides.2007.02.004]

11. Rodas G, Ventura JL, Cadefau JA, Cussó R, Parra J. A short training programme for the rapid improvement of both aerobic and anaerobic metabolism. European journal of applied physiology. 2000;82(5):480-6. [DOI:10.1007/s004210000223]

12. Stensel D. Exercise, appetite and appetite-regulating hormones: implications for food intake and weight control. Annals of nutrition and metabolism. 2010;57(2):36-42. [DOI:10.1159/000322702]

13. Faraji H, Taghipoor Asrami A, Jalali SF, Enferadi F. The effect of concurrent exercise on PYY and NPY plasma levels in obese men. Tabari Biomedical Student Research Journal. 2016;2(1):48-58. (in Persian)

14. Hopkins M, Blundell JE. Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity. Clinical Science. 2016;130(18):1615-28. [DOI:10.1042/CS20160006]

15. Rocha J, Paxman J, Dalton C, Winter E, Broom DR. Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings, and 7-day energy intake and energy expenditure in inactive men. Applied Physiology, Nutrition, and Metabolism. 2016;41(11):1129-36. [DOI:10.1139/apnm-2016-0189]

16. Chen JX, Zhao X, Yue GX, Wang ZF. Influence of Acute and Chronic Treadmill Exercise on Rat Plasma Lactate and Brain NPY, L-ENK, DYN A 1-13. Cellular and molecular neurobiology. 2007;27(1):1-0. [DOI:10.1007/s10571-006-9110-4]

17. Soori R, Mahmoodi F, Ranjbar K, Ramezankhani A, Akbari M. Effects of regular physical activity on levels of nesfatin-1, neuropeptideY and cortisol in obese men. Koomesh. 2017;19(1):64-74. (in Persian)

18. Keshtkar B, Daryanoosh F, Nabizadeh F, Tanideh N, Salesi M. The effect of training program with moderate and high intensity exercises on neuropeptide y hormone and ghrelin in fat asprague-dawley rats. Journal of Advances in Medical and Biomedical Research. 2014;22(94):96-110.

19. Ghanbari-Niaki A. Ghrelin and glucoregulatory hormone responses to a single circuit resistance exercise in male college students. Clinical biochemistry. 2006;39(10):966-70. [DOI:10.1016/j.clinbiochem.2006.05.009]

20. Ataullakhanov FI, Vitvitsky VM. What determines the intracellular ATP concentration. Bioscience reports. 2002;22(5-6):501-11. [DOI:10.1023/A:1022069718709]

21. De Rijke CE, Hillebrand JJ, Verhagen LA, Roeling TA, Adan RA. Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats. Journal of molecular endocrinology. 2005;35(2):381-90. [DOI:10.1677/jme.1.01808]

22. Ramson R, Jurimae J, Jurimae T, Maestu J. The effect of 4-week training period on plasma neuropeptide Y, leptin and ghrelin responses in male rowers. European journal of applied physiology. 2012;112(5):1873-80. [DOI:10.1007/s00421-011-2166-y]

23. Ghiasi E, Manesh MD, Daryanoosh F, Nazemzadeghan G. Effect of eight weeks aerobic exercise on plasma level of agouti-related protein, glycated hemoglobin and glucose in non-active type II diabetic women. Journal of Gorgan University of Medical Sciences. 2015;17(3):89-95. (in Persian)

24. Salehi E, Banitalebi E, Faramarzi M, Bagheri L, Mardanpour Shahrekordi Z. Effects of 8-weeks combined training (strength and endurance) on serum levels of AGRP, GH and changes in appetite and body mass in postmenopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2016;19(28):1-9. (in Persian)

25. Gobadi MR, Rahmaninia F, Mirzaei B, Hedayati M. Effects of 8 weeks of aerobic training on Agouti-related peptide, appetite hormones and insulin resistance in overweight sedentary women. Journal of Jahrom University of Medical Sciences. 2016;14(2). (in Persian) [DOI:10.29252/jmj.14.2.1]

26. de Mello MT, de Piano A, Carnier J, Sanches PD, Correa FA, Tock L, et al. Long‐term effects of aerobic plus resistance training on the metabolic syndrome and adiponectinemia in obese adolescents. The journal of clinical hypertension. 2011;13(5):343-50. [DOI:10.1111/j.1751-7176.2010.00388.x]

27. Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, Pence BD, et al. Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2014;69(6):675-81. [DOI:10.1093/gerona/glt132]

28. Delphan M, Rashidlamir A, Ebrahimi-Atri A, Saadatnia A. The effect of two weight loss protocols on plasma concentration of agouti related peptide (AgRP) in elite wrestlers. Jundishapur Scientific Medical Journal. 2013;12(3):229-41. (in Persian)

29. Horowitz JF. Fatty acid mobilization from adipose tissue during exercise. Trends in Endocrinology & Metabolism. 2003;14(8):386-92. [DOI:10.1016/S1043-2760(03)00143-7]