Volume 4, Number 1 (5-2012)                   IJDO 2012, 4(1): 26-31 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Parsaeyan N, Mozaffari–Khosravi H, Mozayan M R. Effect of Pomegranate Juice on Paraoxonase Enzyme Activity in Patients with Type 2 Diabetes. IJDO. 2012; 4 (1) :26-31
URL: http://ijdo.ssu.ac.ir/article-1-70-en.html

1. Department of Biochemistry, School of Medicine, ShahidSadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (2566 Views)
OBJECTIVE: The aim of this study was to investigate the effect of pomegranate juice (PJ) on the paraoxonase and arylesterase activity of human serum paraoxonase( PON1). MATERIAL AND METHOD: Fifty patients with type 2 diabetes mellitus consumed 200 ml of PJ daily for a period of 6 weeks. Blood was collected from the patients before and after PJ consumption after 12 h of fasting. Blood sugar, total cholesterol, triglyceride, and HDL-C were measured by enzymatic kit method and autoanalyzer. The concentration of LDL-C was calculated by using Friedwald formula. The malondialdehyde concentration (μmol/L) was determined by thiobarbituric acid (TBA) assay. Paraoxonase and arylesterase activity of PON1 enzyme were measured using paraoxone and phenylacetate as the substrates. RESULTS: The concentration of fasting blood sugar, total cholesterol, LDL-C and malondialdehyde significantly (p<0.001) decreased after the intervention. Paraoxonase and arylesterase activity of PON1 significantly (p<0.001) increased after the intervention. However, there were no significant changes in serum triglyceride and HDL-C. There was a significant positive correlation between paraoxonase and arylesterase activity of PON1 and serum HDL-C concentration. A significant negative correlation was detected between paraoxonase and arylesterase activity of PON1 and FBS. CONCLUSION: It can be concluded that PJ consumption as an antioxidant may have a contribution in changing fasting blood sugar, lipid profiles, lipoprotein oxidation, and PON1 activity.
Full-Text [PDF 114 kb]   (546 Downloads)    
Type of Study: Research | Subject: Special
Received: 2012/08/13

Add your comments about this article : Your username or email:
Write the security code in the box

© 2015 All Rights Reserved | Iranian Journal of Diabetes and Obesity

Designed & Developed by : Yektaweb