Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context

Navin Jain, Vatsal; Ghanghurde, Swati; Rajesh Carvalho, Sherwin; Sachin Nirgudkar, Shivani; Vijay Rojekar, Mohit

doi:10.18502/ijdo.v14i3.10738

Volume 14, Issue 3 (volume 14, number 3 2022) IJDO 2022, 14(3): 131-137 | Back to browse issues page

‎ 10.18502/ijdo.v14i3.10738

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Navin Jain V, Ghanghurde S, Rajesh Carvalho S, Sachin Nirgudkar S, Vijay Rojekar M. Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context. IJDO 2022; 14 (3) :131-137
URL: http://ijdo.ssu.ac.ir/article-1-725-en.html

Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context

Vatsal Navin Jain

, Swati Ghanghurde

, Sherwin Rajesh Carvalho

, Shivani Sachin Nirgudkar

, Mohit Vijay Rojekar ^*

Professor & Head, Department of Biochemistry Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India.

Abstract: (700 Views)

Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters.
Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests.
Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL.
Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs.

Keywords: Thyroid hormones, Hypothyroidism, Diabetes mellitus, Glycated haemoglobin A

Full-Text [PDF 214 kb] (242 Downloads)

Type of Study: Research | Subject: Special
Received: 2022/06/12 | Accepted: 2022/07/18 | Published: 2022/09/19

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