دوره 10، شماره 4 - ( 7-1397 )                   جلد 10 شماره 4 صفحات 187-193 | برگشت به فهرست نسخه ها

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Hamedifar M, Mirnasouri R, Rahmati M. The Effects of Six Weeks Endurance Training on XBP-1 Protein in the Diabetic Male Wistar Rats Sciatica Tissues. IJDO. 2018; 10 (4) :187-193
URL: http://ijdo.ssu.ac.ir/article-1-448-fa.html
The Effects of Six Weeks Endurance Training on XBP-1 Protein in the Diabetic Male Wistar Rats Sciatica Tissues. دیابت و چاقی. 1397; 10 (4) :187-193

URL: http://ijdo.ssu.ac.ir/article-1-448-fa.html


چکیده:   (370 مشاهده)
Objective: The aim of this study was to investigate the effect of endurance activity on XBP-1 protein content in sciatica tissue of diabetic male Wistar rats.
Materials and Methods: The experimental design was a post-test design with control group. In this study, 32 male Wistar 10 weeks old rats with the mean weight of 253.16 (±10.16) grams were randomly divided into four groups: healthy control, healthy exercise, diabetic control and diabetic training group. An intraperitoneal injection of STZ (45 mg / kg) solution was used to induce diabetes after 12 hours fasting, 48 hours after STZ injection, the moderate-intensity endurance protocol was performed for 6 weeks. Twenty-four hours after the last training session, the mice were exposed and their sciatic nerve was extracted. The amount of XBP-1 protein was measured by ELISA method. For statistical analysis, SPSS software and two-way ANOVA with repeated measure and independent T-test were used.
Results: Data analysis showed that endurance activity had an effect on the amount of XBP-1 protein and reduced the protein content, so that the difference was significant in the diabetic training group compared to the diabetic control group (P-value: 0.007).
Conclusion: These findings indicated that moderate aerobic exercise has a significant effect on the amount of XBP-1 protein in healthy and diabetic rats.

 
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۸/۳/۷ | پذیرش: ۱۳۹۸/۳/۷ | انتشار: ۱۳۹۸/۳/۷

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