Volume 10, Issue 4 (volume 10, number 4 2018)                   2018, 10(4): 187-193 | Back to browse issues page

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Hamedifar M, Mirnasouri R, Rahmati M. The Effects of Six Weeks Endurance Training on XBP-1 Protein in the Diabetic Male Wistar Rats Sciatica Tissues. Iranian Journal of Diabetes and Obesity 2018; 10 (4) :187-193
URL: http://ijdo.ssu.ac.ir/article-1-448-en.html
Assistant Professor, Department of Sport Physiology, Department of Physical Education and Sports Science, Faculty of Physical Education, Lorestan University, Khorramabad, Iran.
Abstract:   (2128 Views)
Objective: The aim of this study was to investigate the effect of endurance activity on XBP-1 protein content in sciatica tissue of diabetic male Wistar rats.
Materials and Methods: The experimental design was a post-test design with control group. In this study, 32 male Wistar 10 weeks old rats with the mean weight of 253.16 (±10.16) grams were randomly divided into four groups: healthy control, healthy exercise, diabetic control and diabetic training group. An intraperitoneal injection of STZ (45 mg / kg) solution was used to induce diabetes after 12 hours fasting, 48 hours after STZ injection, the moderate-intensity endurance protocol was performed for 6 weeks. Twenty-four hours after the last training session, the mice were exposed and their sciatic nerve was extracted. The amount of XBP-1 protein was measured by ELISA method. For statistical analysis, SPSS software and two-way ANOVA with repeated measure and independent T-test were used.
Results: Data analysis showed that endurance activity had an effect on the amount of XBP-1 protein and reduced the protein content, so that the difference was significant in the diabetic training group compared to the diabetic control group (P-value: 0.007).
Conclusion: These findings indicated that moderate aerobic exercise has a significant effect on the amount of XBP-1 protein in healthy and diabetic rats.

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Type of Study: Research | Subject: Special
Received: 2019/05/28 | Accepted: 2019/05/28 | Published: 2019/05/28

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