دوره 4، شماره 1 - ( 2-1391 )                   جلد 4 شماره 1 صفحات 26-31 | برگشت به فهرست نسخه ها


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Parsaeyan N, Mozaffari–Khosravi H, Mozayan M R. Effect of Pomegranate Juice on Paraoxonase Enzyme Activity in Patients with Type 2 Diabetes. IJDO. 2012; 4 (1) :26-31
URL: http://ijdo.ssu.ac.ir/article-1-70-fa.html
Effect of Pomegranate Juice on Paraoxonase Enzyme Activity in Patients with Type 2 Diabetes. دیابت و چاقی. 1391; 4 (1) :26-31

URL: http://ijdo.ssu.ac.ir/article-1-70-fa.html


چکیده:   (2749 مشاهده)
OBJECTIVE: The aim of this study was to investigate the effect of pomegranate juice (PJ) on the paraoxonase and arylesterase activity of human serum paraoxonase( PON1). MATERIAL AND METHOD: Fifty patients with type 2 diabetes mellitus consumed 200 ml of PJ daily for a period of 6 weeks. Blood was collected from the patients before and after PJ consumption after 12 h of fasting. Blood sugar, total cholesterol, triglyceride, and HDL-C were measured by enzymatic kit method and autoanalyzer. The concentration of LDL-C was calculated by using Friedwald formula. The malondialdehyde concentration (μmol/L) was determined by thiobarbituric acid (TBA) assay. Paraoxonase and arylesterase activity of PON1 enzyme were measured using paraoxone and phenylacetate as the substrates. RESULTS: The concentration of fasting blood sugar, total cholesterol, LDL-C and malondialdehyde significantly (p<0.001) decreased after the intervention. Paraoxonase and arylesterase activity of PON1 significantly (p<0.001) increased after the intervention. However, there were no significant changes in serum triglyceride and HDL-C. There was a significant positive correlation between paraoxonase and arylesterase activity of PON1 and serum HDL-C concentration. A significant negative correlation was detected between paraoxonase and arylesterase activity of PON1 and FBS. CONCLUSION: It can be concluded that PJ consumption as an antioxidant may have a contribution in changing fasting blood sugar, lipid profiles, lipoprotein oxidation, and PON1 activity.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۱/۵/۲۳

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