Volume 2, Issue 2 (4-2010)                   IJDO 2010, 2(2): 1-6 | Back to browse issues page

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Rezvanfar M R, Ghahramani R, Rafiee M, Mokhtari , M R, Ghanbarpoor S. Fasting Hyperglycemia and Insulin Resistance in Colorectal Adenomatous Polyps. IJDO 2010; 2 (2) :1-6
URL: http://ijdo.ssu.ac.ir/article-1-25-en.html
Abstract:   (8666 Views)
OBJECTIVES: To investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. MATERIALS AND METHODS: In this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (IGF-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with Adenomatous polyps). We also estimated homeostasis model assessment insulin resistance index (HOMA-IR) in two groups. Statistical analyses were performed using the Student T-test and Chi-square test. For all tests a P value ≤ 0.05 was considered to be statistically significant. RESULTS: The mean of waist circumference (P < 0.01), waist to hip ratio (P < 0.01), fasting serum glucose (P < 0.05), total cholesterol (P < 0.05), and LDL (P < 0.05) were significantly higher in patients with adenomatous polyps. The mean of HDL was significantly lower in patients with adenomatous polyps (P < 0.01). There was no relation between fasting serum insulin, IGF-1 and glucose tolerance test with adenomatous polyps. Hence HOMA-IR was higher in patients with adenomatous polyps (2.9 ± 2.6 vs. 2.82 ± 2.1), this difference was not significant statistically. CONCLUSION: Fasting hyperglycemia could be a risk factor to adenomatous polyps’ development. Although this study did not show any relation between insulin resistance index and adenomatous polyps, further studies are needed for more evaluation.
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Type of Study: Research | Subject: General
Received: 2011/08/16 | Published: 2010/04/15

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