Volume 7, Issue 4 (volume 7, number4 2015)                   IJDO 2015, 7(4): 146-152 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mostafavi F, Zaridoust A, Setoudeh A. Insulin effect on Leptin Concentration in Children with New Onset Insulin Dependent Diabetes Mellitus. IJDO 2015; 7 (4) :146-152
URL: http://ijdo.ssu.ac.ir/article-1-264-en.html
MD Subspecialist in Pediatric Endocrinology and Metabolism, Guilan Medical University, Guilan, Iran.
Abstract:   (3429 Views)

Objective: Serum Leptin concentration reflects the body fat mass. There is controversial reports about the insulin effect on serum Leptin concentration. We wanted to examine the effect of insulin therapy on serum Leptin in children with new onset type I diabetes.

Materials and Methods: This was a Cross-Sectional study in Children's Medical Center on 34 children who had new onset type I diabetes. Serum Leptin level was measured at presentation, as a baseline before initiation of insulin therapy, three to five days and after three months of beginning of insulin therapy. The linear regression by SPSSv.16 used for analysis.

Results: There was a meaningful difference between the baseline level of Leptin and 3th-5th day. (P=0.00). The dosage of insulin was the most important factor affecting the Leptin levels after three months of treatment (P=0.006). In third months of follow up, sex and insulin dosage were the variables that effected on Leptin level. (P=0.003).

Conclusion: The results of our study showed that children with new-onset type I diabetes have low Leptin level before insulin therapy which increased in 3-5 days after treatment. We concluded that the acute insulin therapy alters the Leptin secretion/ action.

Full-Text [PDF 297 kb]   (1099 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/11/13 | Accepted: 2016/11/13 | Published: 2016/11/13

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Diabetes and Obesity

Designed & Developed by : Yektaweb