Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Wed, Nov 27, 2024
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Volume 8, Issue 3 (9-2016)
IJDO 2016, 8(3): 129-134 |
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Emami A, Homaee H M, Azarbayjani M A. Effects of High Intensity Interval Training and Curcumin Supplement on Glutathione Peroxidase (GPX) Activity and Malondialdehyde (MDA) Concentration of the Liver in STZ Induced Diabetic Rats. IJDO 2016; 8 (3) :129-134
URL: http://ijdo.ssu.ac.ir/article-1-308-en.html
URL: http://ijdo.ssu.ac.ir/article-1-308-en.html
PhD student of Biochemistry and Exercise Metabolism, Islamic Azad University, Central Tehran branch, Tehran, Iran.
Abstract: (4358 Views)
Objective: The purpose of the present study was investigation of eight weeks high intensity interval (HIIT) along with curcumin supplementation on liver Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration among diabetic male rats.
Materials and Methods: Thirty-two male mice were divided to four groups of control-diabetic, exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic. Eight weeks’ aerobic training schedule was five weekly sessions for the two exercise groups, which each session executed on animal treadmill with speed of 24 (m/min), steep of 0°, and entire span of 18 min. The two supplementary groups were being fed daily amount of 50 (mg/kg) curcumin supplementary, by using the gavage technique. The rats were killed and liver tissues were separated, after the eight weeks’ schedule. Thereafter, in order to study variations of GPX and MDA enzymes, Kits of Zelbio Co. were implemented.
Results: Activity levels of GPX enzyme and MDA concentration of the three groups of exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic in order increased and decreased than those of the control-diabetic one, significantly (P≤0.05).
Discussion: both exercise and curcumin can be recommended as effective interventions on improvement of Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration of the liver, in diabetic condition.
Materials and Methods: Thirty-two male mice were divided to four groups of control-diabetic, exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic. Eight weeks’ aerobic training schedule was five weekly sessions for the two exercise groups, which each session executed on animal treadmill with speed of 24 (m/min), steep of 0°, and entire span of 18 min. The two supplementary groups were being fed daily amount of 50 (mg/kg) curcumin supplementary, by using the gavage technique. The rats were killed and liver tissues were separated, after the eight weeks’ schedule. Thereafter, in order to study variations of GPX and MDA enzymes, Kits of Zelbio Co. were implemented.
Results: Activity levels of GPX enzyme and MDA concentration of the three groups of exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic in order increased and decreased than those of the control-diabetic one, significantly (P≤0.05).
Discussion: both exercise and curcumin can be recommended as effective interventions on improvement of Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration of the liver, in diabetic condition.
Type of Study: Research |
Subject:
Special
Received: 2017/08/2 | Accepted: 2017/08/2 | Published: 2017/08/2
Received: 2017/08/2 | Accepted: 2017/08/2 | Published: 2017/08/2
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