Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Tue, Nov 26, 2024
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Volume 8, Issue 4 (12-2016)
IJDO 2016, 8(4): 183-190 |
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Roozbayani M, Peeri M, Agha-Alinejad H, Azarbayjani M A. Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats. IJDO 2016; 8 (4) :183-190
URL: http://ijdo.ssu.ac.ir/article-1-321-en.html
URL: http://ijdo.ssu.ac.ir/article-1-321-en.html
Coach of Exercise Physiology, Department of Exercise Physiology, Boroujerd, Islamic Azad University, Boroujerd, Iran.
Abstract: (3706 Views)
Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.
Keywords: High intensity interval training, Continues aerobic training, Diabetic rats, MIR29A, Collagen I
Type of Study: Research |
Subject:
Special
Received: 2017/09/16 | Accepted: 2017/09/16 | Published: 2017/09/16
Received: 2017/09/16 | Accepted: 2017/09/16 | Published: 2017/09/16
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