Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Fri, Nov 13, 2026
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Volume 9, Issue 4 (12-2017)
Iran J Diabetes Obes. 2017, 9(4): 170-178 |
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Daneshyar S, Koochakkhani H, Almasi J, Forutan Y. The Effect of a Combination of Swim Training and Magnesium Supplementation on Thermal Hyperalgesia in Diabetic Rats. Iran J Diabetes Obes. 2017; 9 (4) :170-178
URL: http://ijdo.ssu.ac.ir/article-1-365-en.html
URL: http://ijdo.ssu.ac.ir/article-1-365-en.html
1- Department of Physical Education and exercise science, University of Ayatollah Alozma Boroujerdi, Boroujerd, Iran.
2- Department of Exercise Physiology, Faculty of Faculty of Sport Science, Bu Ali Sina University, Hamedan, Iran.
3- Department of Physical Education and Sport Sciences, Bahar Branch, Islamic Azad University, Hamedan, Iran.
4- Department of Exercise Physiology, Faculty of Exercise Physiology and Sports Sciences, Razi University, Kermanshah, Iran
2- Department of Exercise Physiology, Faculty of Faculty of Sport Science, Bu Ali Sina University, Hamedan, Iran.
3- Department of Physical Education and Sport Sciences, Bahar Branch, Islamic Azad University, Hamedan, Iran.
4- Department of Exercise Physiology, Faculty of Exercise Physiology and Sports Sciences, Razi University, Kermanshah, Iran
Abstract: (4359 Views)
Objective: A question raised here as to whether exercise training combined with Mg supplementation could improve the symptoms of neuropathic pain such as the thermal hyperalgesia more effectively than either of the two alone. This study aimed to investigate the combined effect of swim training and Mg supplementation on thermal hyperalgesia in streptozotocin (STZ) induced diabetic rats.
Materials and Methods: Male wistar rats were randomly assigned to 5 groups: Control (C), Diabetic Control (CD), Training Diabetic (TD), Magnesium (Mg) Supplementing Diabetic (MgD), and Mg Supplementing and Training (MgTD). The training rats were subjected to forced-swimming for 8 weeks. Mg supplementing groups orally received magnesium sulfate (10 g/l) added into drinking water, for 8 weeks. Tail flick latency (TFL) test was used to evaluate the thermal pain threshold. Data were analyzed via multiple analyses of variance (MANOVA)
Results: Diabetes displayed the thermal hyperalgesia in most of diabetic groups at the late stage diabetes (P<0.05). Long term implementation of either swim training or Mg supplementation alone improved the severity of hyperalgesia (P<0.05). The combination of swim training and Mg administration prevented the occurrence of the hyperalgesia over the course of experiment (P<0.05).
Conclusion: These results suggested that the swim training go along with Mg administration could be a safe effective strategy for the prevention of painful diabetic neuropathy.
Materials and Methods: Male wistar rats were randomly assigned to 5 groups: Control (C), Diabetic Control (CD), Training Diabetic (TD), Magnesium (Mg) Supplementing Diabetic (MgD), and Mg Supplementing and Training (MgTD). The training rats were subjected to forced-swimming for 8 weeks. Mg supplementing groups orally received magnesium sulfate (10 g/l) added into drinking water, for 8 weeks. Tail flick latency (TFL) test was used to evaluate the thermal pain threshold. Data were analyzed via multiple analyses of variance (MANOVA)
Results: Diabetes displayed the thermal hyperalgesia in most of diabetic groups at the late stage diabetes (P<0.05). Long term implementation of either swim training or Mg supplementation alone improved the severity of hyperalgesia (P<0.05). The combination of swim training and Mg administration prevented the occurrence of the hyperalgesia over the course of experiment (P<0.05).
Conclusion: These results suggested that the swim training go along with Mg administration could be a safe effective strategy for the prevention of painful diabetic neuropathy.
Type of Study: Original Article |
Subject:
Diabetes
Received: 2018/02/26 | Accepted: 2018/02/26 | Published: 2018/02/26
Received: 2018/02/26 | Accepted: 2018/02/26 | Published: 2018/02/26
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