Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Sat, Nov 23, 2024
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Volume 11, Issue 2 (6-2019)
IJDO 2019, 11(2): 145-151 |
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Fakourian A, Hasan Matin H, Azarbayjani M A, Farzanegi P. The Effect of Aerobic Training and L- Carnitine on BCL2 and Mitochondrial Enzymes of Rat's Kidney. IJDO 2019; 11 (2) :145-151
URL: http://ijdo.ssu.ac.ir/article-1-492-en.html
URL: http://ijdo.ssu.ac.ir/article-1-492-en.html
Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Abstract: (2181 Views)
Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some mitochondrial enzymes of the kidney in diabetic rats.
Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving L- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than 300 mg/ dL were considered diabetic. L-carnitine recipients received 100 mg of L-carnitine daily orally. The dependent variables of the study were measured 24 hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at P-value< 0.05.
Results: The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl2 factor of kidney tissue of rats with diabetes has a significant effect (P-value: 0.019). But aerobic exercise (P-value: 0.969) and supplementation of L-carnitine (P-value: 0.584) were not significant.
Conclusion: The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT2 and Malonyl COa and Bcl2 have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.
Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving L- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than 300 mg/ dL were considered diabetic. L-carnitine recipients received 100 mg of L-carnitine daily orally. The dependent variables of the study were measured 24 hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at P-value< 0.05.
Results: The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl2 factor of kidney tissue of rats with diabetes has a significant effect (P-value: 0.019). But aerobic exercise (P-value: 0.969) and supplementation of L-carnitine (P-value: 0.584) were not significant.
Conclusion: The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT2 and Malonyl COa and Bcl2 have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.
Type of Study: Research |
Subject:
Special
Received: 2019/11/14 | Accepted: 2019/11/14 | Published: 2019/11/14
Received: 2019/11/14 | Accepted: 2019/11/14 | Published: 2019/11/14
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