Reduced Lung Function and Progression to Prediabetes: A Prospective
Study

Karnain Wadoo, Ovais; Ahmad, Ishtiaq; Sayeed, Sheikh Imran

doi:10.18502/ijdo.v13i4.7994

Volume 13, Issue 4 (12-2021) IJDO 2021, 13(4): 178-183 | Back to browse issues page

‎ 10.18502/ijdo.v13i4.7994

Mendeley

Zotero

RefWorks

Karnain Wadoo O, Ahmad I, Sayeed S I. Reduced Lung Function and Progression to Prediabetes: A Prospective Study. IJDO 2021; 13 (4) :178-183
URL: http://ijdo.ssu.ac.ir/article-1-661-en.html

Reduced Lung Function and Progression to Prediabetes: A Prospective Study

Ovais Karnain Wadoo ^*

, Ishtiaq Ahmad

, Sheikh Imran Sayeed

Senior Resident, Department of Physiology, Government Medical College, Srinagar, India

Abstract: (1165 Views)

Objective: Prediabetes is a state that people have blood glucose levels higher than normal but still not in diabetes range. There is a close relationship between impaired lung function and diabetes mellitus (DM). Reduced lung function can be present before the clinical evidence of diabetes or insulin resistance. Materials and Methods: The total number of subjects in this longitudinal study was 503 and compared with apparently healthy Kashmiri adults. All the subjects, at the time of their first visit, underwent Fasting Plasma Glucose (FPG) estimation, 2- hour oral glucose tolerance test (OGTT) and spirometry (FVC, FEV1 & FEV1/FVC). Those subjects who had normal glucose tolerance (NGT) were retested for glycemic status and spirometric values after a follow-up period of 2-18 (mean=10) months. Results: Out of total 503 subjects on follow up 483 (96%) had NGT and 20 (4%) had prediabetes. Percent predicted forced vital capacity (FVC) and % predicted forced expiratory volume in 1st second (FEV1) were significantly lower (P-value< 0.001) while as % predicted FEV1/FVC was significantly higher (P-value< 0.001) in prediabetes as compared to NGT group. Conclusion: Results of our study point out a predominantly restrictive pattern of lung dysfunction in the prediabetes group as compared to the NGT group.

Keywords: Lung function test, oral glucose tolerance test, Forced vital capacity, Spirometry

Full-Text [PDF 381 kb] (407 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/08/15 | Accepted: 2021/10/8 | Published: 2021/11/1

References

1. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020. Atlanta, GA: Centers for Disease Control and Prevention, US Dept of Health and Human Services.2020.

2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1):S81-90. [DOI:10.2337/dc14-S081]

3. World Health Organization. Global report on diabetes. Geneva: World Health Organization; 2016.

4. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England journal of medicine. 2002;346(6):393-403. [DOI:10.1056/NEJMoa012512]

5. Nichols GA, Hillier TA, Brown JB. Progression from newly acquired impaired fasting glusose to type 2 diabetes. Diabetes care. 2007;30(2):228-33. [DOI:10.2337/dc06-1392]

6. Ramlo-Halsted BA, Edelman SV. The natural history of type 2 diabetes: implications for clinical practice. Primary Care: Clinics in Office Practice. 1999;26(4):771-90. [DOI:10.1016/S0095-4543(05)70130-5]

7. American Diabetes Association. Screening for type 2 diabetes. Diabetes . 2004;27 Suppl 1: S11-4. https://doi.org/10.2337/diacare.27.2007.S11 [DOI:10.2337/diacare.27.2007.S11.]

8. Hsueh WA, Orloski L, Wyne K. Prediabetes: the importance of early identification and intervention. Postgraduate medicine. 2010;122(4):129-43. [DOI:10.3810/pgm.2010.07.2180]

9. Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. Journal of the American College of Cardiology. 2012;59(7):635-43. [DOI:10.1016/j.jacc.2011.08.080]

10. National Institute for Health and Clinical Excellence. Management of chronicobstructive pulmonary disease in adults in primary and secondary care (partial update). 2010.

11. Goldman MD. Lung dysfunction in diabetes. Diabetes care. 2003;26(6):1915-8. [DOI:10.2337/diacare.26.6.1915]

12. Engstrom G, Janzon L. Risk of developing diabetes is inversely related to lung function: a population‐based cohort study. Diabetic medicine. 2002;19(2):167-70. [DOI:10.1046/j.1464-5491.2002.00652.x]

13. Lazarus R, Sparrow D, Weiss ST. Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study. European Respiratory Journal. 1998;12(3):641-5. [DOI:10.1183/09031936.98.12030641]

14. Engström G, Hedblad B, Nilsson P, Wollmer P, Berglund G, Janzon L. Lung function, insulin resistance and incidence of cardiovascular disease: a longitudinal cohort study. Journal of internal medicine. 2003;253(5):574-81. [DOI:10.1046/j.1365-2796.2003.01138.x]

15. Garber AJ, Handelsman Y, Einhorn D, Bergman DA, Bloomgarden ZT, Fonseca V, et al. Diagnosis and management of prediabetes in the continuum of hyperglycemia-when do the risks of diabetes begin? A consensus statement from the American College of Endocrinology and the American Association of Clinical Endocrinologists. Endocrine practice. 2008;14(7):933-46. [DOI:10.4158/EP.14.7.933]

16. Kenealy T, Elley CR, Arrol B. Screening for diabetes and prediabetes Commentary. Lancet 2007; 370(8): 1888-9. https://www.natap.org/2007/HIV/121407_01.htm. [DOI:10.1016/S0140-6736(07)61792-9]

17. Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes care. 2007;30(3):753-9. [DOI:10.2337/dc07-9920]

18. Harris R, Donahue K, Rathore SS, Frame P, Woolf SH, Lohr KN. Screening adults for type 2 diabetes: a review of the evidence for the US Preventive Services Task Force. Annals of internal medicine. 2003;138(3):215-29. [DOI:10.7326/0003-4819-138-3-200302040-00015]

19. Chang CJ, Wu CH, Yao WJ, Yang YC, Wu JS, Lu FH. Relationships of age, menopause and central obesity on cardiovascular disease risk factors in Chinese women. International journal of obesity. 2000;24(12):1699-704. [DOI:10.1038/sj.ijo.0801457]

20. Wen CP, Cheng TY, Tsai SP, Hsu HL, Wang SL. Increased mortality risks of pre-diabetes (impaired fasting glucose) in Taiwan. Diabetes Care. 2005;28(11):2756-61. [DOI:10.2337/diacare.28.11.2756]

21. Nichols GA, Hillier TA, Brown JB. Progression from newly acquired impaired fasting glusose to type 2 diabetes. Diabetes care. 2007;30(2):228-33. [DOI:10.2337/dc06-1392]

22. Arnalich F, Hernanz A, Lopez-Maderuelo D, Pena JM, Camacho J, Madero R, et al. Enhanced acute-phase response and oxidative stress in older adults with type II diabetes. Hormone and Metabolic Research. 2000;32(10):407-12. [DOI:10.1055/s-2007-978662]

23. Walter RE, Beiser A, Givelber RJ, O'Connor GT, Gottlieb DJ. Association between glycemic state and lung function: the Framingham Heart Study. American journal of respiratory and critical care medicine. 2003;167(6):911-6. [DOI:10.1164/rccm.2203022]

24. Cirillo DJ, Agrawal Y, Cassano PA. Lipids and pulmonary function in the third national health and nutrition examination survey. American journal of epidemiology. 2002;155(9):842-8. [DOI:10.1093/aje/155.9.842]

25. Gazis A, Page S, Cockcroft J. Vitamin E and cardiovascular protection in diabetes. British Medical Journal.1997;314(7098):1845-6. [DOI:10.1136/bmj.314.7098.1845]

26. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813-20. [DOI:10.1038/414813a]

27. Kuziemski K, Specjalski K, Jassem E. Diabetic pulmonary microangiopathy-fact or fiction?. Endokrynologia Polska. 2011;62(2):171-6.

28. Klein OL, Krishnan JA, Glick S, Smith LJ. Systematic review of the association between lung function and Type 2 diabetes mellitus. Diabetic medicine. 2010;27(9):977-87. [DOI:10.1111/j.1464-5491.2010.03073.x]

29. Nandhini R, Safina SS, Saikumar P. Respiratory myopathy in type II diabetes mellitus. Journal of Clinical and Diagnostic Research. 2012;6(3):354-57.

30. Yamane T, Yokoyama A, Kitahara Y, Miyamoto S, Haruta Y, Hattori N, et al. Cross-sectional and prospective study of the association between lung function and prediabetes. BMJ open. 2013;3(2):e002179. [DOI:10.1136/bmjopen-2012-002179]

31. Li Y, Saito M, Tobimatsu S, Oshida H, Hori Y, Fuchigami H, et al. Prediabetes and impaired lung function in asymptomatic adults. Diabetes research and clinical practice. 2013;100(2):e51-4. [DOI:10.1016/j.diabres.2013.01.021]