First Trimester Potential Biochemical Predictive Tests for Gestational Diabetes Mellitus: A Systematic Review

Darvish, Soodabeh; Rashidi Fakari, Farzaneh; Haghdoost , Simin

doi:10.18502/ijdo.v13i4.8002

Volume 13, Issue 4 (12-2021) IJDO 2021, 13(4): 234-247 | Back to browse issues page

‎ 10.18502/ijdo.v13i4.8002

Mendeley

Zotero

RefWorks

Darvish S, Rashidi Fakari F, Haghdoost S. First Trimester Potential Biochemical Predictive Tests for Gestational Diabetes Mellitus: A Systematic Review. IJDO 2021; 13 (4) :234-247
URL: http://ijdo.ssu.ac.ir/article-1-668-en.html

First Trimester Potential Biochemical Predictive Tests for Gestational Diabetes Mellitus: A Systematic Review

Soodabeh Darvish

, Farzaneh Rashidi Fakari

, Simin Haghdoost ^*

Department of Midwifery, Urmia Branch, Islamic Azad University, Urmia, Iran.

Abstract: (1176 Views)

Objective: Gestational diabetes mellitus (GDM) is the most common metabolic complication during pregnancy. So, a large number of studies have evaluated the usefulness of different screening tests. The aim of this study was focused on the potential of only first-trimester screening used in the prediction of GDM.
Materials and Methods: In this systematic review, we searched PubMed, EMBASE, and Scopus (between 2010 and 2020) and also searched the reference lists of the relevant articles manually. After performing a thorough evaluation of the 242 potentially eligible papers, only 60 papers were selected in terms of the inclusion criteria. Search key terms were combining ‘Gestational diabetes’ or ‘GD’ “gestational diabetes mellitus” or” GDM” or pregnancy-induced diabetes’ with at least one of the following terms: “screening test”, “first-trimester”, “prediction”, “marker predictor”, “serum marker”.
Results: A total of 161954 pregnant women were evaluated in these reviewed studies. Moreover, many tests were assessed in the first trimester of pregnancy to predict GDM. This review showed that hs-CRP, FPG, TG, and LDL-C along with maternal BMI in the first trimester were related to the increased risk of developing GDM. Other tests were used in only one or two studies.
Conclusion: This review showed that hs-CRP, FPG, TG, and LDL-C along with maternal BMI in the first trimester were linked to an increased risk of developing GDM. It is recommended that further well-designed studies by considering the cost-effective advantages of these predictive tests, should be performed.

Keywords: Gestational diabetes, First trimester, Biomarker, Review

Full-Text [PDF 727 kb] (452 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/05/21 | Accepted: 2021/10/7 | Published: 2021/11/1

References

1. Jelliffe‐Pawlowski LL, Baer RJ, Blumenfeld YJ, Ryckman KK, O'Brodovich HM, Gould JB, et al. Maternal characteristics and mid‐pregnancy serum biomarkers as risk factors for subtypes of preterm birth. BJOG: An International Journal of Obstetrics & Gynaecology. 2015;122(11):1484-93. [DOI:10.1111/1471-0528.13495]

2. Sweeting A, Park F, Hyett J. The first trimester: prediction and prevention of the great obstetrical syndromes. Best practice & research Clinical obstetrics & gynaecology. 2015;29(2):183-93. [DOI:10.1016/j.bpobgyn.2014.09.006]

3. Lowe WL, Scholtens DM, Sandler V, Hayes MG. Genetics of gestational diabetes mellitus and maternal metabolism. Current diabetes reports. 2016;16(2):15. [DOI:10.1007/s11892-015-0709-z]

4. Seshiah V, Balaji V, Balaji MS, Paneerselvam A, Arthi T, Thamizharasi M, et al. Prevalence of gestational diabetes mellitus in South India (Tamil Nadu): a community based study. Journal of Association Physical of India. 2008;56:329-3.

5. Correa PJ, Venegas P, Palmeiro Y, Albers D, Rice G, Roa J, et al. First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study. Journal of perinatal medicine. 2019;47(2):161-8. [DOI:10.1515/jpm-2018-0120]

6. Kumru P, Arisoy R, Erdogdu E, Demirci O, Kavrut M, Ardıc C, et al. Prediction of gestational diabetes mellitus at first trimester in low-risk pregnancies. Taiwanese Journal of Obstetrics and Gynecology. 2016;55(6):815-20. [DOI:10.1016/j.tjog.2016.04.032]

7. Lovati E, Beneventi F, Simonetta M, Laneri M, Quarleri L, Scudeller L, et al. Gestational diabetes mellitus: including serum pregnancy-associated plasma protein-A testing in the clinical management of primiparous women? A case-control study. Diabetes research and clinical practice. 2013;100(3):340-7. [DOI:10.1016/j.diabres.2013.04.002]

8. Kapustin RV, Kascheeva TK, Alekseenkova EN, Shelaeva EV. Are the first-trimester levels of PAPP-A and fb-hCG predictors for obstetrical complications in diabetic pregnancy?. The Journal of Maternal-Fetal & Neonatal Medicine. 2020:1-7. [DOI:10.1080/14767058.2020.1743658]

9. Caliskan R, Atis A, Aydin Y, Acar D, Kiyak H, Topbas F. PAPP-A concentrations change in patients with gestational diabetes. Journal of Obstetrics and Gynaecology. 2020;40(2):190-4. [DOI:10.1080/01443615.2019.1615041]

10. Wang C, Zhu W, Wei Y, Su R, Feng H, Lin L, et al. The predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus stratified by body mass index. Journal of Diabetes Research. 2016;2016. [DOI:10.1155/2016/3013567]

11. Tao Z, WeiPing Y, XiPeng W, XiaoYong L, Jun Z, Little J,et al. A simple model to predict risk of gestational diabetes mellitus from 8 to 20 weeks of gestation in Chinese women. BMC Pregnancy and Childbirth. 2019;19(252). [DOI:10.1186/s12884-019-2374-8]

12. Iliodromiti S, Sassarini J, Kelsey TW, Lindsay RS, Sattar N, Nelson SM. Accuracy of circulating adiponectin for predicting gestational diabetes: a systematic review and meta-analysis. Diabetologia. 2016;59(4):692-9. [DOI:10.1007/s00125-015-3855-6]

13. Aker SŞ, Yüce T, Kalafat E, Seval M, Söylemez F. Association of first trimester serum uric acid levels gestational diabetes mellitus development. Turkish journal of obstetrics and gynecology. 2016;13(2):71. [DOI:10.4274/tjod.69376]

14. Behboudi-Gandevani S, Safary K, Moghaddam-Banaem L, Lamyian M, Goshtasbi A, Alian-Moghaddam N. The relationship between maternal serum iron and zinc levels and their nutritional intakes in early pregnancy with gestational diabetes. Biological trace element research. 2013;154(1):7-13. [DOI:10.1007/s12011-013-9703-y]

15. Inan C, Varol FG, Erzincan SG, Uzun I, Sutcu H, Sayin NC. Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and PROK1/PAPP-A ratio to predict adverse pregnancy outcomes in the first trimester: a prospective study. The Journal of Maternal-Fetal & Neonatal Medicine. 2018;31(20):2685-92. [DOI:10.1080/14767058.2017.1351536]

16. Tu WJ, Guo M, Shi XD, Cai Y, Liu Q, Fu CW. First-trimester serum fatty acid-binding protein 4 and subsequent gestational diabetes mellitus. Obstetrics & Gynecology. 2017;130(5):1011-6. [DOI:10.1097/AOG.0000000000002310]

17. Alamolhoda SH, Haghdoost S, Shariatifar N, Zare E, Ahmadi Doulabi M. The Relationship between Risk of Attention Deficit Hyperactivity Disorder (ADHD) in Low Birth Weight Children: A Systematic Review. International Journal of Pediatrics. 2020.

18. Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T. First trimester maternal serum screening using biochemical markers PAPP-A and free β-hCG for down syndrome, patau syndrome and edward syndrome. Indian Journal of Clinical Biochemistry. 2013;28(1):3-12. [DOI:10.1007/s12291-012-0269-9]

19. Cheuk QK, Lo TK, Wong SF, Lee CP. Association between pregnancy-associated plasma protein-A levels in the first trimester and gestational diabetes mellitus in Chinese women. Hong Kong Med J. 2016;22(1):30-8. [DOI:10.12809/hkmj144470]

20. Kulaksizoglu S, Kulaksizoglu M, Kebapcilar AG, Torun AN, Ozcimen E, Turkoglu S. Can first-trimester screening program detect women at high risk for gestational diabetes mellitus?. Gynecological Endocrinology. 2013;29(2):137-40. [DOI:10.3109/09513590.2012.708800]

21. Husslein H, Lausegger F, Leipold H, Worda C. Association between pregnancy-associated plasma protein-A and gestational diabetes requiring insulin treatment at 11-14 weeks of gestation. The Journal of Maternal-Fetal & Neonatal Medicine. 2012;25(11):2230-3. [DOI:10.3109/14767058.2012.684170]

22. Savvidou MD, Syngelaki A, Muhaisen M. First trimester maternal serum free human chorionic gonadotropin and pregnancy-associated plasma protein A in (2011). [DOI:10.1111/j.1471-0528.2011.03253.x]

23. Ryckman KK, Spracklen CN, Smith CJ, Robinson JG, Saftlas AF. Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta‐analysis. Bjog: an international journal of obstetrics & gynaecology. 2015;122(5):643-51. [DOI:10.1111/1471-0528.13261]

24. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone?. Diabetes care. 2003;26(8):2442-50. [DOI:10.2337/diacare.26.8.2442]

25. Corcoran SM, Achamallah N, O'Loughlin J, Stafford P, Dicker P, Malone FD, et al. First trimester serum biomarkers to predict gestational diabetes in a high-risk cohort: Striving for clinically useful thresholds. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018;222:7-12. [DOI:10.1016/j.ejogrb.2017.12.051]

26. Almoznino-Sarafian D, Berman S, Mor A, Shteinshnaider M, Gorelik O, Tzur I, et al. Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?. European journal of nutrition. 2007;46(4):230-7. [DOI:10.1007/s00394-007-0655-x]

27. Ozgu-Erdinc AS, Yilmaz S, Yeral MI, Seckin KD, Erkaya S, Danisman AN. Prediction of gestational diabetes mellitus in the first trimester: comparison of C-reactive protein, fasting plasma glucose, insulin and insulin sensitivity indices. The Journal of Maternal-Fetal & Neonatal Medicine. 2015;28(16):1957-62. [DOI:10.3109/14767058.2014.973397]

28. Kansu-Celik H, Ozgu-Erdinc AS, Kisa B, Findik RB, Yilmaz C, Tasci Y. Prediction of gestational diabetes mellitus in the first trimester: comparison of maternal fetuin-A, N-terminal proatrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels. Archives of endocrinology and metabolism. 2019;63:121-7. [DOI:10.20945/2359-3997000000126]

29. Naser W, Adam I, Rayis DA, Ahmed MA, Hamdan HZ. Serum magnesium and high-sensitivity C-reactive protein as a predictor for gestational diabetes mellitus in Sudanese pregnant women. BMC pregnancy and childbirth. 2019;19(1):1-5. [DOI:10.1186/s12884-019-2429-x]

30. Zhang T, Du T, Li W, Yang S, Liang W. Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development. Biomarkers in medicine. 2018;12(3):239-44. [DOI:10.2217/bmm-2016-0030]

31. Caudana AE, Ridaura RL, Villalpando CG, Ponce EC, y López EM, Ávila MH, et al. Prediction of alterations in glucose metabolism by glucose and insulin measurements in early pregnancy. Archives of medical research. 2011;42(1):70-6. [DOI:10.1016/j.arcmed.2011.01.010]

32. Weykamp C. HbA1c: a review of analytical and clinical aspects. Annals of laboratory medicine. 2013;33(6):393-400. [DOI:10.3343/alm.2013.33.6.393]

33. Amylidi S, Mosimann B, Stettler C, Fiedler GM, Surbek D, Raio L. First‐trimester glycosylated hemoglobin in women at high risk for gestational diabetes. Acta obstetricia et gynecologica Scandinavica. 2016;95(1):93-7. [DOI:10.1111/aogs.12784]

34. Claire B, Sharon H. Should HbA1C be used to screen pregnant women for undiagnosed diabetes in the first trimester? A review of the evidence. Journal of Public Health. 2020;42(1):132-40. [DOI:10.1093/pubmed/fdy229]

35. Juhan‐Vague I, Alessi MC, Mavri A, Morange PE. Plasminogen activator inhibitor‐1, inflammation, obesity, insulin resistance and vascular risk. Journal of Thrombosis and Haemostasis. 2003;1(7):1575-9. [DOI:10.1046/j.1538-7836.2003.00279.x]

36. Savvidou M, Nelson SM, Makgoba M, Messow CM, Sattar N, Nicolaides K. First-trimester prediction of gestational diabetes mellitus: examining the potential of combining maternal characteristics and laboratory measures. Diabetes. 2010;59(12):3017-22. [DOI:10.2337/db10-0688]

37. Kühl C. Insulin secretion and insulin resistance in pregnancy and GDM: implications for diagnosis and management. Diabetes. 1991;40(Supplement 2):18-24. [DOI:10.2337/diab.40.2.S18]

38. Grewal E, Kansara S, Kachhawa G, Ammini A, Kriplani A, Aggarwal N, et al. Prediction of gestational diabetes mellitus at 24 to 28 weeks of gestation by using first-trimester insulin sensitivity indices in Asian Indian subjects. Metabolism. 2012;61(5):715-20. [DOI:10.1016/j.metabol.2011.10.009]

39. Falcone V, Kotzaeridi G, Breil MH, Rosicky I, Stopp T, Yerlikaya-Schatten G, et al. Early assessment of the risk for gestational diabetes mellitus: can fasting parameters of glucose metabolism contribute to risk prediction?. Diabetes & metabolism journal. 2019;43(6):785-93. [DOI:10.4093/dmj.2018.0218]

40. Zhang D, Zhang L, Zheng Y, Yue F, Russell RD, Zeng Y. Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients. Diabetes research and clinical practice. 2014;106(2):312-8. [DOI:10.1016/j.diabres.2014.08.017]

41. Mokkala K, Tertti K, Rönnemaa T, Vahlberg T, Laitinen K. Evaluation of serum zonulin for use as an early predictor for gestational diabetes. Nutrition & diabetes. 2017;7(3):e253. [DOI:10.1038/nutd.2017.9]

42. Bawah AT, Seini MM, Yakubu YA, Ussher FA, Amoah BY, Alidu H. First trimester zonulin levels and adiposity as predictive indices of gestational diabetes mellitus. International Journal of Diabetes in Developing Countries. 2019 Jul;39(3):451-7. [DOI:10.1007/s13410-019-00715-4]

43. Schneuer FJ, Roberts CL, Guilbert C, Simpson JM, Algert CS, Khambalia AZ, et al. Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population. The American journal of clinical nutrition. 2014;99(2):287-95. [DOI:10.3945/ajcn.113.065672]

44. Makgoba M, Nelson SM, Savvidou M, Messow CM, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes care. 2011;34(5):1091-3. [DOI:10.2337/dc10-2264]

45. Savvidou MD, Akolekar R, Samaha RB, Masconi AP, Nicolaides KH. Maternal serum 25‐hydroxyvitamin D levels at 11+ 0-13+ 6 weeks in pregnant women with diabetes mellitus and in those with macrosomic neonates. BJOG: An International Journal of Obstetrics & Gynaecology. 2011;118(8):951-5. [DOI:10.1111/j.1471-0528.2011.02982.x]

46. Baker AM, Haeri S, Camargo Jr CA, Stuebe AM, Boggess KA. First‐trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case‐control study. Diabetes/metabolism research and reviews. 2012;28(2):164-8. [DOI:10.1002/dmrr.1282]

47. Zhang MX, Pan GT, Guo JF, Li BY, Qin LQ, Zhang ZL. Vitamin D deficiency increases the risk of gestational diabetes mellitus: a meta-analysis of observational studies. Nutrients. 2015;7(10):8366-75. [DOI:10.3390/nu7105398]

48. Lekva T, Godang K, Michelsen AE, Qvigstad E, Normann KR, Norwitz ER, et al. Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 weeks' gestation. Scientific reports. 2018;8(1):1-9. [DOI:10.1038/s41598-018-31614-z]

49. Yeral MI, Ozgu-Erdinc AS, Uygur D, Seckin KD, Karsli MF, Danisman AN. Prediction of gestational diabetes mellitus in the first trimester, comparison of fasting plasma glucose, two-step and one-step methods: a prospective randomized controlled trial. Endocrine. 2014 Aug;46(3):512-8. [DOI:10.1007/s12020-013-0111-z]