Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus

Aljanabi, Mustafa Ali Hasan; Homayouni Tabrizi, Masoud; Pouresmaeil, Vahid

doi:10.18502/ijdo.v14i1.8738

Volume 14, Issue 1 (2-2022) IJDO 2022, 14(1): 20-28 | Back to browse issues page

‎ 10.18502/ijdo.v14i1.8738

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Aljanabi M A H, Homayouni Tabrizi M, Pouresmaeil V. Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus. IJDO 2022; 14 (1) :20-28
URL: http://ijdo.ssu.ac.ir/article-1-683-en.html

Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus

Mustafa Ali Hasan Aljanabi

, Masoud Homayouni Tabrizi

, Vahid Pouresmaeil ^*

Department of Biochemistry, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.Innovative Medical Research Center, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.

Abstract: (1260 Views)

Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen receptor (AR) and the enzyme 5-alpha reductase (5αR). Therefore, this study aimed to investigate the relationship between these factors in T2DM.
Materials and Methods: This case-control study was performed with 60 volunteers, including 30 diabetics and 30 healthy individuals. Demographic information of individuals was recorded and levels of CYP450, 5αR, and AR were measured in serum by ELISA. Data were analyzed by SPSS v.26 version and the significance level was less than 5%.
Results: There were no significant difference between diabetics and healthy individuals in gender (P= 1), body mass index (P= 0.199), diastolic pressure(P= 0.466), uric acid(P= 0.202), creatinine(P= 0.627), low-density lipoprotein (P= 0.572), high-density lipoprotein(P=0.692); But there was a significant difference in systolic pressure(P= 0.034), triglyceride(P= 0.0001), and insulin(P= 0.003), between diabetics and healthy individuals. The distribution of CYP450, 5αR and AR in two groups shows that the level of all three factors is higher in diabetic people (P= 0.0001). Also, glycosylated hemoglobin and insulin have a direct relationship with CYP450 (P= 0.0001, R=0.494; P= 0.043, R=0.263), 5αR (P= 0.0001, R=0.808; P= 0.016, R=0.309) and with AR (P= 0.0001, R=0.836; P= 0.011, R=0.326).
Conclusion: These results showed that there was a relationship between the levels of CYP450, 5αR, and ARs with T2DM which may explain hormonal changes in diabetic people and the different responses to treatment.

Keywords: Diabetes mellitus, Cytochrome P450, 5-alpha reductase, Androgen receptor

Full-Text [PDF 694 kb] (413 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/09/28 | Accepted: 2022/01/8 | Published: 2022/02/26

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