Volume 14, Issue 4 (volume 14, number 4 2022)                   IJDO 2022, 14(4): 223-230 | Back to browse issues page


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Ahmadi Majd S, Rabbani Khorasgani M, Zaker S R, Khezri M, Aliasghari Veshareh A. Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (ANGIPARS) on Wound Healing of Diabetic Rats. IJDO 2022; 14 (4) :223-230
URL: http://ijdo.ssu.ac.ir/article-1-748-en.html
Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran.
Abstract:   (177 Views)
Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats.
Materials and Methods: For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2) wound was surgically induced in the dorsal region of each rat. The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately. The control groups were including non-diabetic and untreated diabetic rats.
Results: The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%. RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.
Conclusion: Regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.
Full-Text [PDF 1857 kb]   (68 Downloads)    
Type of Study: Research | Subject: Special
Received: 2022/07/18 | Accepted: 2022/10/4 | Published: 2022/11/19

References
1. Armstrong DG, Boulton AJ, Bus SA. Diabetic foot ulcers and their recurrence. New England Journal of Medicine. 2017;376(24):2367-75. [DOI:10.1056/NEJMra1615439]
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36 Suppl 1(Suppl 1):S67-74. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537273/. [DOI:10.2337/dc13-S067]
3. Dilworth L, Facey A, Omoruyi F. Diabetes mellitus and its metabolic complications: the role of adipose tissues. International Journal of Molecular Sciences. 2021;22(14):7644. [DOI:10.3390/ijms22147644]
4. Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian journal of endocrinology and metabolism. 2016;20(4):546-51. [DOI:10.4103/2230-8210.183480]
5. Houreld NN. Shedding light on a new treatment for diabetic wound healing: a review on phototherapy. The Scientific World Journal. 2014. [DOI:10.1155/2014/398412]
6. Gonzalez AC, Costa TF, Andrade ZD, Medrado AR. Wound healing-A literature review. Anais brasileiros de dermatologia. 2016;91:614-20. [DOI:10.1590/abd1806-4841.20164741]
7. Pendsey SP. Understanding diabetic foot. International journal of diabetes in developing countries. 2010;30(2):75. [DOI:10.4103/0973-3930.62596]
8. Iraj B, Khorvash F, Ebneshahidi A, Askari G. Prevention of diabetic foot ulcer. International journal of preventive medicine. 2013;4(3):373-6.
9. Naves CC. The diabetic foot: a historical overview and gaps in current treatment. Advances in wound care. 2016;5(5):191-7. [DOI:10.1089/wound.2013.0518]
10. Khosravi F. A Brief Review about the Effect of Honey on Diabetic Foot Ulcer; from In Vitro Studies to Clinical Trials. Research Journal of Pharmacognosy. 2019;6(3):85-91.
11. Erejuwa OO. Effect of honey in diabetes mellitus: matters arising. Journal of diabetes & metabolic disorders. 2014;13(1):1-4. [DOI:10.1186/2251-6581-13-23]
12. Fratini F, Cilia G, Mancini S, Felicioli A. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiological research. 2016;192:130-41. [DOI:10.1016/j.micres.2016.06.007]
13. Zhang S, Shao Q, Geng H, Su S. The effect of royal jelly on the growth of breast cancer in mice. Oncology letters. 2017;14(6):7615-21. [DOI:10.3892/ol.2017.7078]
14. Shidfar F, Jazayeri S, Mousavi SN, Malek M, Hosseini F, Khoshpey B. Does supplementation with royal jelly improve oxidative stress and insulin resistance in type 2 diabetic patients?. Iranian journal of public health. 2015;44(6):797.
15. Suemaru K, Cui R, Li B, Watanabe S, Okihara K, Hashimoto K, et al. Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters. Methods and findings in experimental and clinical pharmacology. 2008;30(2):103-6. [DOI:10.1358/mf.2008.30.2.1159655]
16. Bakhshayeshi S, Madani SP, Hemmatabadi M, Heshmat R, Larijani B. Effects of Semelil (ANGIPARS (TM)) on diabetic peripheral neuropathy: A randomized, double-blind Placebo-controlled clinical trial. Daru. 2011;19(1):65.
17. Ranjbar H. Overview of diabetic foot; novel treatments in diabetic foot ulcer. DARU Journal of Pharmaceutical Sciences. 2008;16(Suppl. 1):1-6.
18. Mostafavinia A, Amini A, Ghorishi SK, Pouriran R, Bayat M. The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of typel diabetes mellitus and mortality rate in rats. Laboratory animal research. 2016;32(3):160-5. [DOI:10.5625/lar.2016.32.3.160]
19. Suzuki Y, Imada T, Yamaguchi I, Yoshitake H, Sanada H, Kashiwagi T, et al. Effects of prolonged water washing of tissue samples fixed in formalin on histological staining. Biotechnic & Histochemistry. 2012;87(4):241-8. [DOI:10.3109/10520295.2011.613410]
20. Masoompour SM, Bagheri MH, Novitsky YA, Sadeghi B, Gharibdoust F, Larijani B. Effect of ANGIPARSTM, a new herbal drug on diabetic foot ulcer: A phase 2 clinical study. DARU Journal of Pharmaceutical Sciences. 2008;16(Suppl. 1):31-4.
21. Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M. Does Royal jelly affect tumor cells?. Journal of HerbMed Pharmacology. 2013;2(2).
22. Siavash M, Shokri S, Haghighi S, Mohammadi M, Shahtalebi MA, Farajzadehgan Z. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2011;16(7):904.
23. Abdelatif M, Yakoot M, Etmaan M. Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study. Journal of wound care. 2008 ;17(3):108-10. [DOI:10.12968/jowc.2008.17.3.28667]

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