Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial

Kordestani, Shiva; Razavi, Seyyed Behzad; Najaf Najafi, Mona; Layegh, Parvin; Miri Moghaddam, Mohammadmobin; Aali, Amirali; Mohebbi, Masoud

doi:10.18502/ijdo.v15i1.12206

Volume 15, Issue 1 (3-2023) IJDO 2023, 15(1): 7-13 | Back to browse issues page

‎ 10.18502/ijdo.v15i1.12206

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Kordestani S, Razavi S B, Najaf Najafi M, Layegh P, Miri Moghaddam M, Aali A et al . Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial. IJDO 2023; 15 (1) :7-13
URL: http://ijdo.ssu.ac.ir/article-1-773-en.html

Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial

Shiva Kordestani

, Seyyed Behzad Razavi

, Mona Najaf Najafi

, Parvin Layegh

, Mohammadmobin Miri Moghaddam

, Amirali Aali

, Masoud Mohebbi ^*

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract: (714 Views)

Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.
Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant.
Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably.
Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.

Keywords: Clinical trial, Diabetes mellitus, Blood glucose, HbA1C, HDL, LDL, Ascorbic acid

Full-Text [PDF 203 kb] (459 Downloads)

Type of Study: Research | Subject: Special
Received: 2022/09/12 | Accepted: 2023/12/22 | Published: 2023/03/19

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