Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial

Kordestani, Shiva; Razavi, Seyyed Behzad; Najaf Najafi, Mona; Layegh, Parvin; Miri Moghaddam, Mohammadmobin; Aali, Amirali; Mohebbi, Masoud

doi:10.18502/ijdo.v15i1.12206

Volume 15, Issue 1 (volume 15, number 1 2023) IJDO 2023, 15(1): 7-13 | Back to browse issues page

‎ 10.18502/ijdo.v15i1.12206

Mendeley

Zotero

RefWorks

Kordestani S, Razavi S B, Najaf Najafi M, Layegh P, Miri Moghaddam M, Aali A et al . Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial. IJDO 2023; 15 (1) :7-13
URL: http://ijdo.ssu.ac.ir/article-1-773-en.html

Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial

Shiva Kordestani

, Seyyed Behzad Razavi

, Mona Najaf Najafi

, Parvin Layegh

, Mohammadmobin Miri Moghaddam

, Amirali Aali

, Masoud Mohebbi ^*

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract: (486 Views)

Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.
Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant.
Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably.
Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.

Keywords: Clinical trial, Diabetes mellitus, Blood glucose, HbA1C, HDL, LDL, Ascorbic acid

Full-Text [PDF 203 kb] (206 Downloads)

Type of Study: Research | Subject: Special
Received: 2022/09/12 | Accepted: 2023/12/22 | Published: 2023/03/19

References

1. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific reports. 2020;10(1):1-1. [DOI:10.9734/JSRR/2016/23459]

2. Xu G, Liu B, Sun Y, Du Y, Snetselaar LG, Hu FB, Bao W. Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study. Bmj. 2018;362. [DOI:10.1136/bmj.k1497]

3. Luc K, Schramm-Luc A, Guzik TJ, Mikolajczyk TP. Oxidative stress and inflammatory markers in prediabetes and diabetes. J Physiol Pharmacol. 2019;70(6):809-24.

4. Dakhale GN, Chaudhari HV, Shrivastava M. Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind study. Advances in Pharmacological and Pharmaceutical Sciences. 2011;2011. [DOI:10.1155/2011/195271]

5. Darvish Moghaddam S, Moshtaghi Kashanian GH, Hayatbakhsh M, Mehdipour A. Effect of pharmacologic doses of vitamin C on glycosylated hemoglobin in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism. 2002;4(1):15-21.(in Persian)

6. Forghani B, Gohariyan V, Kassaian N, Amini M. The effect of vitamin C supplements on glycated hemoglobin in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism. 2000;2(4):233-7.(in Persian)

7. Hamed AT, Al Zinati SM, Al Swirky A. The Effect of Vitamin C Alone or in Combination with Vitamin E on Fasting Blood Glucose, Glycosylated Hemoglobin and Lipid Profile inType 2 Diabetic Patients (Gaza Strip). Jordan Journal of Pharmaceutical Sciences. 2016;403(3638):1-2. [DOI:10.12816/0029864]

8. Gęgotek A, Skrzydlewska E. Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid. Antioxidants. 2022;11(10):1993. [DOI:10.3390/antiox11101993]

9. Chen L, Jia RH, Qiu CJ, Ding G. Hyperglycemia inhibits the uptake of dehydroascorbate in tubular epithelial cell. American journal of nephrology. 2005;25(5):459-65. [DOI:10.1159/000087853]

10. Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and antimicrobial effects of vitamin C. European Journal of Microbiology and Immunology. 2019;9(3):73-9. [DOI:10.1556/1886.2019.00016]

11. Puvvada RC. Association of vitamin C status in diabetes mellitus: prevalence and predictors of vitamin C deficiency. Future Journal of Pharmaceutical Sciences. 2020;6:1-5. [DOI:10.1186/s43094-020-00040-2]

12. Gillani SW, Sulaiman SA, Abdul MI, Baig MR. Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial. Cardiovascular diabetology. 2017;16:1-3. [DOI:10.1186/s12933-017-0584-9]

13. Mason SA, Keske MA, Wadley GD. Effects of vitamin C supplementation on glycemic control and cardiovascular risk factors in people with type 2 diabetes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Diabetes Care. 2021;44(2):618-30. [DOI:10.2337/dc20-1893]

14. Christie-David DJ, Girgis CM, Gunton JE. Effects of vitamins C and D in type 2 diabetes mellitus. Nutrition and Dietary Supplements. 2015;7:21-8. [DOI:10.2147/NDS.S52022]

15. Das UN. Vitamin C for type 2 diabetes mellitus and hypertension. Archives of medical research. 2019 ;50(2):11-4. [DOI:10.1016/j.arcmed.2019.05.004]

16. Kunsongkeit P, Okuma N, Rassameemasmaung S, Chaivanit P. Effect of vitamin C as an adjunct in nonsurgical periodontal therapy in uncontrolled type 2 diabetes mellitus patients. European journal of dentistry. 2019;13(03):444-9. [DOI:10.1055/s-0039-1693207]

17. Afkhami-Ardekani M, Shojaoddiny-Ardekani A. Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients. Indian Journal of medical research. 2007;126(5):471-4.