Effect of Concurrent Resistance-Aerobic Training on Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Pediatric Type 1 Diabetes: A Randomized Trial

Nazari, Marzieh; Shabani, Ramin; Dalili, Setila

doi:10.18502/ijdo.v15i1.12211

Volume 15, Issue 1 (volume 15, number 1 2023) IJDO 2023, 15(1): 51-58 | Back to browse issues page

‎ 10.18502/ijdo.v15i1.12211

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Nazari M, Shabani R, Dalili S. Effect of Concurrent Resistance-Aerobic Training on Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Pediatric Type 1 Diabetes: A Randomized Trial. IJDO 2023; 15 (1) :51-58
URL: http://ijdo.ssu.ac.ir/article-1-778-en.html

Effect of Concurrent Resistance-Aerobic Training on Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Pediatric Type 1 Diabetes: A Randomized Trial

Marzieh Nazari

, Ramin Shabani ^*

, Setila Dalili

Department of Exercise Physiology, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.

Abstract: (344 Views)

Objective: The role of post-exercise on the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is not evident in pediatrics with type 1 diabetes (T1D) yet. This paper reports the results of a research study on how concurrent exercise training affects NLR and PLR in children with T1D.
Materials and Methods: In this randomized controlled trial, 40 children (boys and girls aged 11.11 ±2.29 years) were randomly divided into an experimental (n=20) and a control group (n=20). The training program included concurrent resistance-aerobic training, which was intermittently performed for 60 minutes at a rate of three times a week for 16 weeks. The participants were analyzed for blood glucose homeostasis, NLR and PLR before and after the program. Data were analyzed by SPSS 22 software with paired T-test and covariance analysis (P< 0.05).
Results: The results showed that PLR significantly (P= 0.002) decreased in the exercise group after 16 weeks of concurrent training. This significance was observed between the groups too (P= 0.003). HbA1c decreased both in the exercise group and between the groups (P= 0.001, P= 0.003). NLR exhibited a significant increase both in the exercise group (P= 0.021( and between the groups )P= 0.012(.
Conclusion: Concurrent exercise training reduces PLR and HbA1c in children with T1D, which may be related to the anti-inflammatory effects of exercise training.

Keywords: Diabetes mellitus, Neutrophil- lymphocyte ratio, Platelet-lymphocyte ratio, Pediatric

Full-Text [PDF 228 kb] (166 Downloads)

Type of Study: Research | Subject: Special
Received: 2022/10/21 | Accepted: 2023/01/7 | Published: 2023/03/19

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