Evaluation of Restless Leg Syndrome in Patients with Type 2 Diabetes Mellitus

Khalid, Tayyaba; Afzal, M Faheem; Amjad, Aneela

doi:10.18502/ijdo.v15i2.12966

Volume 15, Issue 2 (volume 15, number 2 2023) IJDO 2023, 15(2): 87-92 | Back to browse issues page

‎ 10.18502/ijdo.v15i2.12966

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Khalid T, Afzal M F, Amjad A. Evaluation of Restless Leg Syndrome in Patients with Type 2 Diabetes Mellitus. IJDO 2023; 15 (2) :87-92
URL: http://ijdo.ssu.ac.ir/article-1-791-en.html

Evaluation of Restless Leg Syndrome in Patients with Type 2 Diabetes Mellitus

Tayyaba Khalid ^*

, M Faheem Afzal

, Aneela Amjad

PSRD College of Rehabilitation Sciences, Lahore, Pakistan.

Abstract: (379 Views)

Objective: To evaluate restless leg syndrome (RLS) in type 2 Diabetes Mellitus (T2DM) in Lahore.
Materials and Methods: A cross-sectional study design was recruited for this study. Non-probability purposive sampling technique was used to select the patients in the study. The data was collected from the Pakistan Society for the Rehabilitation of Disabled (PSRD) Hospital and Hameed Latif Hospital Lahore. Patients diagnosed with T2DM with a maximum of 10 years, ages between 35 to 65 years, and patients who suffer from minor complications of diabetes mellitus were in
cluded in the study. The RLS rating scale was used to assess the severity of restlessness in participants.
Results: Out of 144 subjects, the frequency of the RLS was 71.5% and the majority was more in females as compared to male subjects. The female subjects have moderate severity of RLS while male subjects have mild severity of RLS.
Conclusion: The frequency of RLS was high in patients with T2DM and females were more prone to RLS as compared to male subjects.

Keywords: Frequency, Restless leg syndrome, Type 2 diabetes mellitus

Full-Text [PDF 394 kb] (146 Downloads)

Type of Study: Research | Subject: Special
Received: 2023/01/6 | Accepted: 2023/04/12 | Published: 2023/06/20

References

1. Atlas D. International diabetes federation. IDF Diabetes Atlas, 7th edn. Brussels, Belgium: International Diabetes Federation. 2015;33:2.

2. Flores-Hernández S, Saturno-Hernandez PJ, Reyes-Morales H, Barrientos-Gutierrez T, Villalpando S, Hernandez-Avila M. Quality of diabetes care: the challenges of an increasing epidemic in Mexico. Results from two national health surveys (2006 and 2012). PloS one. 2015;10(7):e0133958.

3. Arokiasamy P, Uttamacharya, Kowal P, Capistrant BD, Gildner TE, Thiele E, et al. Chronic noncommunicable diseases in 6 low-and middle-income countries: findings from wave 1 of the World Health Organization's study on global Ageing and adult health (SAGE). American journal of epidemiology. 2017;185(6):414-28.

4. Alotaibi A, Perry L, Gholizadeh L, Al-Ganmi A. Incidence and prevalence rates of diabetes mellitus in Saudi Arabia: an overview. Journal of epidemiology and global health. 2017;7(4):211-8.

5. Lone S, Lone K, Khan S, Pampori RA. Assessment of metabolic syndrome in Kashmiri population with type 2 diabetes employing the standard criteria's given by WHO, NCEPATP III and IDF. Journal of epidemiology and global health. 2017;7(4):235-9.

6. Seuring T, Archangelidi O, Suhrcke M. The economic costs of type 2 diabetes: a global systematic review. Pharmacoeconomics. 2015:811-31.

7. Al Slail FY, Abid O, Assiri AM, Memish ZA, Ali MK. Cardiovascular risk profiles of adults with type-2 diabetes treated at urban hospitals in Riyadh, Saudi Arabia. Journal of epidemiology and global health. 2016;6(1):29-36.

8. Surani S, Brito V, Surani A, Ghamande S. Effect of diabetes mellitus on sleep quality. World journal of diabetes. 2015;6(6):868.

9. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement_1):S81-90.

10. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ. Type 2 diabetes mellitus. Nature reviews Disease primers. 2015; 1 (1): 1-22.

11. Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of diabetes 2017. Journal of diabetes research. 2018;2018.

12. Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum?. Indian journal of endocrinology and metabolism. 2016;20(4):546.

13. Akın S, Bölük C, Börü ÜT, Taşdemir M, Gezer T, Şahbaz FG, et al. Restless legs syndrome in type 2 diabetes mellitus. Primary care diabetes. 2019;13(1):87-91.

14. Kambampati S, Wasim S, Kukkar V, Awad VM, Malik BH. Restless leg syndrome in the setting of patients with end-stage renal disease on hemodialysis: a literature review. Cureus. 2020;12(8).

15. Wijemanne S, Jankovic J. Restless legs syndrome: clinical presentation diagnosis and treatment. Sleep medicine. 2015 Jun 1;16(6):678-90.

16. Allen RP. Restless leg syndrome/Willis-Ekbom disease pathophysiology. Sleep medicine clinics. 2015;10(3):207-14.

17. Becker PM, Novak M. Diagnosis, comorbidities, and management of restless legs syndrome. Current medical research and opinion. 2014;30(8):1441-60.

18. Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, et al. Comorbidities, treatment, and pathophysiology in restless legs syndrome. The Lancet Neurology. 2018;17(11):994-1005.

19. Walters AS, Frauscher B, Allen R, Benes H, Chaudhuri KR, Garcia-Borreguero D, et al. Review of diagnostic instruments for the restless legs syndrome/Willis-Ekbom Disease (RLS/WED): critique and recommendations. Journal of Clinical Sleep Medicine. 2014;10(12):1343-9. [DOI:10.5664/jcsm.4298]

20. Zobeiri M, Shokoohi A. Restless leg syndrome in diabetics compared with normal controls. Sleep disorders. 2014;2014.

21. Cho YW, Na GY, Lim JG, Kim SH, Kim HS, Earley CJ, et al. Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis. Sleep medicine. 2013;14(12):1387-92.

22. Merlino G, Valente M, Serafini A, Fratticci L, Del Giudice A, Piani A, et al. Effects of restless legs syndrome on quality of life and psychological status in patients with type 2 diabetes. The Diabetes Educator. 2010;36(1):79-87.

23. Ning P, Hu F, Yang B, Shen Q, Zhao Q, Huang H, et al. Systematic review and meta-analysis of observational studies to understand the prevalence of restless legs syndrome in multiple sclerosis: an update. Sleep Medicine. 2018;50:97-104.

24. Didriksen M, Rigas AS, Allen RP, Burchell BJ, Di Angelantonio E, Nielsen MH, et al. Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study. Sleep medicine. 2017;36:55-61.

25. Sharon D, Allen RP, Martinez-Martin P, Walters AS, Strambi LF, Högl B, et al. Validation of the self-administered version of the international Restless Legs Syndrome study group severity rating scale-the sIRLS. Sleep medicine. 2019;54:94-100.

26. Harashima SI, Nishimura A, Osugi T, Wang Y, Liu Y, Takayama H, et al. Restless legs syndrome in patients with type 2 diabetes: effectiveness of pramipexole therapy. BMJ supportive & palliative care. 2016;6(1):89-93.

27. Mirghani H. Restless legs syndrome among Sudanese patients with type 2 diabetes mellitus: a case-control study. Cureus. 2020;12(8).

28. Nawaz MS, Nawaz MS, Shah KU, ul Mustafa Z, Ahmed A, Ahmed HS, et al. Prevalence and determinants of restless leg syndrome in type 2 diabetes mellitus (T2DM) in Pakistan. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021;15(2):525-8.

29. Afkhami-Ardekani A, Momayez-Sanat Z, Vahhabi Z, Vazirpanah T, Afkhami-Ardekani M. The relationship between frequency of restless leg syndrome and type 2 diabetes. Iranian Journal of Diabetes and Obesity. 2017;9(1):40-4.

30. Ning P, Mu X, Yang X, Li T, Xu Y. Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies. EClinicalMedicine. 2022 ;46:101357.

31. Modarresnia L, Golgiri F, Madani NH, Emami Z, Tanha K. Restless legs syndrome in Iranian people with type 2 diabetes mellitus: the role in quality of life and quality of sleep. Journal of clinical sleep medicine. 2018;14(2):223-8.