Volume 15, Issue 2 (volume 15, number 2 2023)                   IJDO 2023, 15(2): 93-101 | Back to browse issues page

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Delbari R, Fathi R, Safarzade A, Nasiri K. Investigating the Levels of Liver Lipogenic and Lipolytic Enzymes in Rat with High-Fat Diet and Sucrose Solution Underwent Progressive Resistance Training. IJDO 2023; 15 (2) :93-101
URL: http://ijdo.ssu.ac.ir/article-1-792-en.html
Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran. Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran.
Abstract:   (181 Views)
Objective: Consuming too much fat or carbohydrates stimulates lipogenesis and excess fat is stored in non-fat tissues, including the liver, and manifests as obesity and fatty liver disease. This study aimed to investigate the effect of eight weeks of progressive resistance training (PRT) on the liver levels of some enzymes affecting lipid metabolism in rats fed a high-fat diet and sucrose solution.
Materials and Methods: Twenty-four male wistar rats with 5 weeks of age were randomly divided into two groups: standard diet (SD) (n=8) and high-fat diet and sucrose solution (HFDS) (n=16). Twelve weeks later, HFDS group was divided into two groups: sedentary (HS) and PRT (HPRT). The PRT program was implemented 3 days a week for 8 weeks. Gene expression of AMPKα1, SCD-1, ATGL and FASN enzymes affecting lipid metabolism in liver tissue and its fat content were investigated.
Results: HFDS significantly increased the body weight (P: 0.001) and significantly decreased the liver expression of ATGL and FASN (P: 0.001, P: 0.011). Eight weeks of PRT did not show a significant difference in the expression of AMPKα1, SCD-1, ATGL and FASN genes. Rats fed HFDS had considerably higher levels of triglyceride (TG) and total cholesterol (TC) in their liver tissue (P: 0.004, P: 0.001) and PRT did not affect them (P: 0.959, P: 0.809 respectively).
Conclusion: It seems that eight weeks of PRT will not change liver lipid metabolism enzymes. Therefore, modifying the diet and changing it, will probably show different results after PRT.
Keywords: Liver, Enzymes, Exercise, Diet
Full-Text [PDF 576 kb]   (97 Downloads)    
Type of Study: Research | Subject: Special
Received: 2023/01/15 | Accepted: 2023/04/2 | Published: 2023/06/20

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