The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men

Bahram, Mohammad Ebrahim; Afroundeh, Roghayyeh; Pourvaghar, Mohammad Javad; Seify Skishahr, Farnaz; Katebi, Leila; Isik, Ozkan

doi:10.18502/ijdo.v15i3.13733

Volume 15, Issue 3 (10-2023) IJDO 2023, 15(3): 129-138 | Back to browse issues page

‎ 10.18502/ijdo.v15i3.13733

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Bahram M E, Afroundeh R, Pourvaghar M J, Seify Skishahr F, Katebi L, Isik O. The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men. IJDO 2023; 15 (3) :129-138
URL: http://ijdo.ssu.ac.ir/article-1-813-en.html

The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men

Mohammad Ebrahim Bahram

, Roghayyeh Afroundeh ^*

, Mohammad Javad Pourvaghar

, Farnaz Seify Skishahr

, Leila Katebi

, Ozkan Isik

Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.

Abstract: (403 Views)

Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM).
Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes.
Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups.
Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.

Corresponding Author: Roghayyeh Afroundeh
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Keywords: Interleukin 6, Salusin-α, Salusin-β, Diabetes, Elderly

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Type of Study: Research | Subject: Special
Received: 2023/04/29 | Accepted: 2023/09/5 | Published: 2023/09/30

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