Volume 15, Issue 3 (volume 15, number 3 2023)                   IJDO 2023, 15(3): 175-180 | Back to browse issues page

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Qureshi F, Khoharo H K. Serum Chromium is Inversely Correlated with the Carotid Intima– Media Thickness in Type 2 Diabetic Subjects. IJDO 2023; 15 (3) :175-180
URL: http://ijdo.ssu.ac.ir/article-1-818-en.html
Consultant Physician Professor Faculty of Medicine and Allied Medical Sciences Isra University, Hyderabad, Sindh, Pakistan.
Abstract:   (107 Views)
Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects.
Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P≤ 0.05).
Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001).  Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT.
Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.
Full-Text [PDF 218 kb]   (37 Downloads)    
Type of Study: Research | Subject: Special
Received: 2023/05/9 | Accepted: 2023/08/10 | Published: 2023/09/30

1. Khodavirdipour A, Haddadi F, Keshavarzi S. Chromium supplementation; negotiation with diabetes mellitus, hyperlipidemia and depression. Journal of Diabetes & Metabolic Disorders. 2020;19(1):585-95. [DOI:10.1007/s40200-020-00501-8]
2. Dworzański W, Sembratowicz I, Cholewińska E, Tutaj K, Fotschki B, Juśkiewicz J, et al. Effects of different chromium compounds on hematology and inflammatory cytokines in rats fed high-fat diet. Frontiers in Immunology. 2021;12:614000. [DOI:10.3389/fimmu.2021.614000]
3. Asbaghi O, Naeini F, Ashtary-Larky D, Kaviani M, Kelishadi MR, Eslampour E, e al. Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 2021;60:102755. [DOI:10.1016/j.ctim.2021.102755]
4. Lee YM, Wolf P, Hauner H, Skurk T. Effect of a fermented dietary supplement containing chromium and zinc on metabolic control in patients with type 2 diabetes: a randomized, placebo-controlled, double-blind cross-over study. Food & nutrition research. 2016;60(1):30298. [DOI:10.3402/fnr.v60.30298]
5. Bumrungpert A, Pavadhgul P, Chongsuwat R, Komindr S. Nutraceutical improves glycemic control, insulin sensitivity, and oxidative stress in hyperglycemic subjects: a randomized, double-blind, placebo-controlled clinical trial. Natural Product Communications. 2020;15(4):1934578X20918687. [DOI:10.1177/1934578X20918687]
6. Rabinovitz, Friedensohn, Leibovitz, Gabay, Rocas, Habot. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. International journal for vitamin and nutrition research. 2004;74(3):178-82. [DOI:10.1024/0300-9831.74.3.178]
7. Balk EM, Tatsioni A, Lichtenstein AH, Lau J, Pittas AG. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes care. 2007;30(8):2154-63. [DOI:10.2337/dc06-0996]
8. Hasan HG, Ismael PA, Aziz NM. Evaluation of Serum Chromium Levels in Patients with Type1 and 2 Diabetes Mellitus and insulin resistance. Int J Basic App Sci. 2012;12(4):69-73.
9. Rajpathak S, Rimm EB, Li T, Morris JS, Stampfer MJ, Willett WC, et al. Lower toenail chromium in men with diabetes and cardiovascular disease compared with healthy men. Diabetes Care. 2004;27(9):2211-6. [DOI:10.2337/diacare.27.9.2211]
10. Elabid BH, Ahmed AM. Serum Chromium, Manganese, Zinc and Hemoglobin A 1c% in Sudanese with Type 2 Diabetes. Life Sciences Journal.2014;11(9):320-2.
11. Yeghiazaryan K, H Schild H, Golubnitschaja O. Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders). 2012;12(5):332-9. [DOI:10.2174/187152612804142215]
12. Althuis MD, Jordan NE, Ludington EA, Wittes JT. Glucose and insulin responses to dietary chromium supplements: a meta-analysis. The American journal of clinical nutrition. 2002;76(1):148-55. [DOI:10.1093/ajcn/76.1.148]
13. Mostafa HK. Effect of Diabetes Mellitus on the Structure of Skeletal Muscle in Adult Male Albino Rats and the Protective Role of Chromium: Histological and Immunohistochemical Study. Egyptian Journal of Histology.2008;31(2):341-53.
14. Hajra B, Orakzai SA, Faryal U, Hassan M, Rasheed S, Wazir S. Insulin sensitivity to trace metals (chromium, manganese) in type 2 diabetic patients and non diabetic individuals. Journal of Ayub Medical College Abbottabad. 2016;28(3):534-6.
15. Yoon HE, Kim ES, Mo EY, Shin SJ, Moon SD, Han JH. High normal albuminuria is associated with arterial stiffness and carotid atherosclerosis in Korean patients with type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases. 2015;25(8):787-94. [DOI:10.1016/j.numecd.2015.03.011]
16. Den Ruijter HM, Peters SA, Anderson TJ, Britton AR, Dekker JM, Eijkemans MJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. Jama. 2012;308(8):796-803. [DOI:10.1001/jama.2012.9630]
17. Rajendran K, Manikandan S, Nair LD, Karuthodiyil R, Vijayarajan N, Gnanasekar R, et al. Serum chromium levels in type 2 diabetic patients and its association with glycaemic control. Journal of clinical and diagnostic research.2015;9(11):OC05. [DOI:10.7860/JCDR/2015/16062.6753]
18. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III).Journal of American Medical Association.2001;285(19):2486-97. [DOI:10.1001/jama.285.19.2486]
19. Prasad A. Role of chromium compounds in diabetes. Indian J. Pharm. Pharmacol. 2016;3(1):17-23. [DOI:10.5958/2393-9087.2016.00007.8]
20. Chen YL, Lin JD, Hsia TL, Mao FC, Hsu CH, Pei D. The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes. European journal of nutrition. 2014;53:127-33. [DOI:10.1007/s00394-013-0508-8]
21. Volpe SL, Huang HW, Larpadisorn K, Lesser II. Effect of chromium supplementation and exercise on body composition, resting metabolic rate and selected biochemical parameters in moderately obese women following an exercise program. Journal of the American College of Nutrition. 2001;20(4):293-306. [DOI:10.1080/07315724.2001.10719050]
22. Ding W, Chai Z, Duan P, Feng W, Qian Q. Serum and urine chromium concentrations in elderly diabetics. Biological trace element research. 1998;63:231-7. [DOI:10.1007/BF02778941]
23. Diwan AG, Pradhan AB, Lingojwar D, Krishna KK, Singh P, Almelkar SI. Serum zinc, chromium and magnesium levels in Type 2 diabetes. International Journal of Diabetes in Developing Countries.2006; 26(3):122-23. [DOI:10.4103/0973-3930.32172]
24. Bahijri SM, Mufti AM. Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biological trace element research. 2002;85:97-109. [DOI:10.1385/BTER:85:2:097]
25. Olsén L, Lind PM, Lind L. Gender differences for associations between circulating levels of metals and coronary risk in the elderly. International journal of hygiene and environmental health. 2012;215(3):411-7. [DOI:10.1016/j.ijheh.2011.11.004]
26. Nsonwu AC, Usoro CA, Etukudo MH, Usoro IN. Influence of Age, Gender and Duration of Diabetes on Serum and Urine Levels of Zinc, Magnesium, Seleniumand Chromium in Type 2 Diabetics in Calabar, Nigeria. Türk Biyokimya Dergisi. 2006;31(3):107-14.
27. Sundararaman PG, Sridhar GR, Sujatha V, Anita V. Serum chromium levels in gestational diabetes mellitus. Indian Journal of Endocrinology and Metabolism.2012;16(Suppl1):S70. [DOI:10.4103/2230-8210.94266]
28. Ali NA, Ma Y, Reynolds J, Wise Sr JP, Inzucchi SE, Katz DL. Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. Endocrine Practice. 2011;17(1):16-25. [DOI:10.4158/EP10131.OR]
29. Rafiei R, Habyby Z, Fouladi L, Najafi S, Asgary S, Torabi Z. Chromium level in prediction of diabetes in pre-diabetic patients. Advanced biomedical research. 2014;3:235. [DOI:10.4103/2277-9175.145737]
30. Ulas M, Orhan C, Tuzcu M, Ozercan IH, Sahin N, Gencoglu H, et al. Anti-diabetic potential of chromium histidinate in diabetic retinopathy rats. BMC complementary and alternative medicine. 2015;15:1-8. [DOI:10.1186/s12906-015-0537-3]

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