Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review

Thennakoon, Sachini M; Withanage, Niroshima D

doi:10.18502/ijdo.v15i4.14557

Volume 15, Issue 4 (volume 15, number 4 2023) IJDO 2023, 15(4): 243-255 | Back to browse issues page

‎ 10.18502/ijdo.v15i4.14557

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Thennakoon S M, Withanage N D. Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review. IJDO 2023; 15 (4) :243-255
URL: http://ijdo.ssu.ac.ir/article-1-835-en.html

Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review

Sachini M Thennakoon ^*

, Niroshima D Withanage

Department of Biomedical Sciences, Faculty of Science, NSBM Green University, Mahenwatta, Pitipana, Homagama (10206), Sri Lanka

Abstract: (225 Views)

The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.

Keywords: Gamma-glutamyl transferase, Type 2 diabetes mellitus, Body mass index

Full-Text [PDF 489 kb] (135 Downloads)

Type of Study: Research | Subject: Special
Received: 2023/08/8 | Accepted: 2023/10/15 | Published: 2023/12/19

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