A Comparison of Renal Effects between Empagliflozin and Linagliptin in Diabetic Patients with Chronic Kidney Disease: A Randomized Clinical Trial

Zeinabadi Noghabi, Reza; Rouintan, Rojin; Sabaghian, Tahereh; Khalili, Shayesteh

doi:10.18502/ijdo.v16i2.15706

Volume 16, Issue 2 (volume 16, number 2 2024) IJDO 2024, 16(2): 66-77 | Back to browse issues page

‎ 10.18502/ijdo.v16i2.15706

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Zeinabadi Noghabi R, Rouintan R, Sabaghian T, Khalili S. A Comparison of Renal Effects between Empagliflozin and Linagliptin in Diabetic Patients with Chronic Kidney Disease: A Randomized Clinical Trial. IJDO 2024; 16 (2) :66-77
URL: http://ijdo.ssu.ac.ir/article-1-870-en.html

A Comparison of Renal Effects between Empagliflozin and Linagliptin in Diabetic Patients with Chronic Kidney Disease: A Randomized Clinical Trial

Reza Zeinabadi Noghabi ^*

, Rojin Rouintan

, Tahereh Sabaghian

, Shayesteh Khalili

Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract: (170 Views)

Objective: The current study aimed to compare the renal effects of Empagliflozin with Linagliptin combined with Metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease.
Materials and Methods: We conducted a randomized clinical trial on diabetic patients aged over 18 years with chronic renal failure and an EGFR between 20 to 60 ml/minutes/1.73 m² corrected with the MDRD equation. Between January and December 2023, a total of 150 cases in Imam Hossein Hospital were randomized into two study arms of 75 cases receiving Empagliflozin (10 mg/day) and metformin or Linagliptin (5mg/day) and metformin for 6 months. The primary outcome was a change in chronic kidney disease (CKD) stage, while serum creatinine, fasting blood sugar (FBS), proteinuria, and blood pressure were evaluated at baseline, 3 and 6 months later.
Results: The mean age of participants was 62.20 (± 4.45) years and 50% of them were females. Study indices including serum creatinine (P: 0.001), estimated glomerular filtration rate (eGFR) (P: 0.001), FBS (P: 0.001), HgA1c (P: 0.001), proteinuria (P: 0.001), and blood pressure (P: 0.001) reduced significantly over time in both groups. After adjustment for potential confounders, Empagliflozin reduced the level of serum creatinine independent of other factors.
Conclusion: Empagliflozin significantly reduces the level of serum creatinine compared to Linagliptin in patients with T2DM and chronic renal failure.

Keywords: Chronic renal failure, Diabetes mellitus, Empagliflozin, Linagliptin

Full-Text [PDF 579 kb] (117 Downloads)

Type of Study: Research | Subject: Special
Received: 2023/12/28 | Accepted: 2024/03/21 | Published: 2024/06/21

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