Prevalence and Impact of Thyroid Disorders on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Salimian, Mohammad Reza; Injinari, Nastaran; Azizi, Reyhaneh; Nikkhah, Haniyeh; Namiranian, Nasim

Volume 16, Issue 3 (8-2024) IJDO 2024, 16(3): 138-143 | Back to browse issues page

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Salimian M R, Injinari N, Azizi R, Nikkhah H, Namiranian N. Prevalence and Impact of Thyroid Disorders on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study. IJDO 2024; 16 (3) :138-143
URL: http://ijdo.ssu.ac.ir/article-1-882-en.html

Prevalence and Impact of Thyroid Disorders on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Mohammad Reza Salimian

, Nastaran Injinari

, Reyhaneh Azizi

, Haniyeh Nikkhah

, Nasim Namiranian ^*

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract: (281 Views)

Objective: Diabetes and thyroid disorders (TD) are two prevalent endocrine conditions in adults. While the association between TD and type 1 diabetes is well documented, the relationship between type 2 diabetes mellitus (T2DM) and TD remains unclear due to its complex mechanisms and the involvement of multiple variables. This study aimed to evaluate the prevalence of TD in patients with T2DM referred to Yazd Diabetes Research Center in 2019.
Materials and Methods: This cross-sectional descriptive study included 411 patients with T2DM. Data were collected using a checklist comprising demographic information (age, sex, type of drug used, duration of diabetes) and clinical and laboratory information. Data were analyzed using SPSS version 24 software.
Results: Among the 411 patients with T2DM, 352 (85.6%) had no TD, 38 (9.24%) had hypothyroidism, and 21 (5.10%) had hyperthyroidism. There were no significant differences among groups in terms of gender (P= 0.269), age (P= 0.154), fasting blood sugar (FBS) level (P= 0.196), type of treatment (P= 0.9), and duration of T2DM (P= 0.138). However, a significant relationship was found between TD and the average level of glycosylated hemoglobin (HbA1c) (P= 0.021).
Conclusion: This study highlights a significant prevalence of TD among patients with T2DM, particularly noting the impact on HbA1c levels. Regular screening for TD in patients with T2DM is recommended to improve glycemic control and overall diabetes management. Further research is needed to elucidate the mechanisms linking TD and T2DM and to develop targeted interventions.

Keywords: Type 2 diabetics mellitus, Thyroid disorders, Glycated Hemoglobin A, Prevalence

Full-Text [PDF 450 kb] (116 Downloads)

Type of Study: Research | Subject: Special
Received: 2024/02/25 | Accepted: 2024/06/1 | Published: 2024/08/20

References

1. Mehrabbeik A, Azizi R, Rahmanian M, Namiranian N, Shukohifar M, Asi M. Design and Psychometrics of Diabetes Knowledge Questionnaire. Journal of Medical Education. 2022;21(1):1-9. [DOI:10.5812/jme-130597]

2. Injinari N, Ghoshouni H, Mehrabbeik A, Namiranian N, Ghadiri-Anari A, Azizi R. Comparison of Diabetic Ketoacidosis Characteristics During-and Before the COVID-19 Pandemic. International Journal of Endocrinology and Metabolism. 2023;21(3):134882. [DOI:10.5812/ijem-134882]

3. Asadollahi S, Hadizadeh M, Namiranian N, Kalantar SM, Firoozabadi AD, Injinari N. Misexpression of LINC01410, FOSL1, and MAFB in peripheral blood mononuclear cells associated with diabetic nephropathy. Gene. 2023;862:147265. [DOI:10.1016/j.gene.2023.147265]

4. Al-Geffari M, Ahmad NA, Al-Sharqawi AH, Youssef AM, AlNaqeb D, Al-Rubeaan K. Risk factors for thyroid dysfunction among type 2 diabetic patients in a highly diabetes mellitus prevalent society. International journal of endocrinology. 2013;2013(1):417920. [DOI:10.1155/2013/417920]

5. Moradi S, Mohammadi SM, Namiranian N, Afkhami-Ardekani M, Afkhami-Ardakani O. The Effect of Oral Selenium on the Size of Thyroid Nodules in Patients with Benign Thyroid nodules: A Brief Study. Iranian journal of diabetes and obesity.2022;14(4):219-222. [DOI:10.18502/ijdo.v14i4.11229]

6. Sakyi SA, Ameyaw B, Laing EF, Anthony R, Ephraim RK, Effah A, Kwayie AA, et al. Thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus patients in Ghana: A comparative cross‐sectional study. Endocrinology, Diabetes & Metabolism.2023;6(6):e447. [DOI:10.1002/edm2.447]

7. Jain VN, Ghanghurde S, Carvalho SR, Nirgudkar SS, Rojekar MV. Effect of thyroid hormone levels on glycemic control: The Indian context. Iranian journal of diabetes and obesity.2022;14(3):131-37. [DOI:10.18502/ijdo.v14i3.10738]

8. Duntas LH, Orgiazzi J, Brabant G. The interface between thyroid and diabetes mellitus. Clinical endocrinology. 2011;75(1):1-9. [DOI:10.1111/j.1365-2265.2011.04029.x]

9. Palma CC, Pavesi M, Nogueira VG, Clemente EL, Vasconcellos MD, Pereira LC, et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetology & metabolic syndrome.2013;5:58. [DOI:10.1186/1758-5996-5-58]

10. Gopinath B, Wang JJ, Kifley A, Wall JR, Leeder SR, Mitchell P. Type 2 diabetes does not predict incident thyroid dysfunction in the elderly. Diabetes research and clinical practice. 2008;82(3):e11-3. [DOI:10.1016/j.diabres.2008.08.017]

11. Ogbonna SU, Ezeani IU. Risk factors of thyroid dysfunction in patients with type 2 diabetes mellitus. Frontiers in endocrinology.2019;10:440. [DOI:10.3389/fendo.2019.00440]

12. Jali MV, Kambar S, Jali SM, Pawar N, Nalawade P. Prevalence of thyroid dysfunction among type 2 diabetes mellitus patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017;11Suppl 1:S105-S108. [DOI:10.1016/j.dsx.2016.12.017]

13. Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among greek type 2 diabetic patients attending an outpatient clinic. Journal of clinical medicine research. 2010;2(2):75. [DOI:10.4021/jocmr2010.03.281w]

14. Ozair M, Noor S, Raghav A, Siddiqi SS, Chugtai AM, Ahmad J. Prevalence of thyroid disorders in North Indian Type 2 diabetic subjects: A cross sectional study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2018;12(3):301-4. [DOI:10.1016/j.dsx.2017.12.016]

15. Diez JJ, Sánchez P, Iglesias P. Prevalence of thyroid dysfunction in patients with type 2 diabetes. Experimental and Clinical Endocrinology & Diabetes.2011;119(04):201-7. [DOI:10.1055/s-0031-1271691]

16. Desideri G, Bocale R, D'Amore AM, Carnassale G, Necozione S, Barini A, et al. Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. Internal and emergency medicine.2020;15(1):67-71. [DOI:10.1007/s11739-019-02065-9]

17. Elgazar EH, Esheba NE, Shalaby SA, Mohamed WF. Thyroid dysfunction prevalence and relation to glycemic control in patients with type 2 diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13(4):2513-7. [DOI:10.1016/j.dsx.2019.07.020]

18. Biondi B, Kahaly GJ, Robertson RP. Thyroid dysfunction and diabetes mellitus: two closely associated disorders. Endocrine reviews. 2019;40(3):789-824. [DOI:10.1210/er.2018-00163]

19. Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. International journal of clinical practice. 2010;64(8):1130-9. [DOI:10.1111/j.1742-1241.2010.02376.x]

20. Kalra S, Aggarwal S, Khandelwal D. Thyroid dysfunction and type 2 diabetes mellitus: screening strategies and implications for management. Diabetes Therapy. 2019;10(6):2035-44. [DOI:10.1007/s13300-019-00700-4]