Effect of Resistance and Interval Training on Serum Melatonin and Expression of Its Receptors (MTNR1A and MTNR1B) in the Pancreas Tissue of Diabetic Rats

Karkehabadi, Saeed; Matinhomaee, Hasan; Dehghan Ghahfarokhi, Shahla

doi:10.18502/ijdo.v18i2.21646

Volume 18, Issue 2 (6-2026) IJDO 2026, 18(2): 88-97 | Back to browse issues page

‎ 10.18502/ijdo.v18i2.21646

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Karkehabadi S, Matinhomaee H, Dehghan Ghahfarokhi S. Effect of Resistance and Interval Training on Serum Melatonin and Expression of Its Receptors (MTNR1A and MTNR1B) in the Pancreas Tissue of Diabetic Rats. IJDO 2026; 18 (2) :88-97
URL: http://ijdo.ssu.ac.ir/article-1-1036-en.html

Effect of Resistance and Interval Training on Serum Melatonin and Expression of Its Receptors (MTNR1A and MTNR1B) in the Pancreas Tissue of Diabetic Rats

Saeed Karkehabadi

, Hasan Matinhomaee ^*

, Shahla Dehghan Ghahfarokhi

Department of Exercise physiology, CT.C, Islamic Azad University, Tehran, Iran.

Abstract: (162 Views)

Objective: In addition to controlling seasonal and circadian rhythms, melatonin has been recognized as a potential gene associated with type 2 diabetes (T2D). This study aimed to investigate the impact of resistance and interval training on serum melatonin and its receptors expression (MTNR1A, MTNR1B) in pancreatic tissue of type 2 diabetic rats.
Materials and Methods: To achieve this, T2D was established in 21 male Wistar rats through an 8-week high-fat diet followed by an intraperitoneal injection of STZ (25 ml/kg), then were divided to control (no exercise), resistance (resistance training), and interval (interval training) groups. Exercise interventions lasted 8 weeks (5 time/weekly). Fasting glucose, serum insulin and melatonin, beta cell function, MTNR1A and MTNR1B expression in pancreatic tissue were assessed 48 hours following lasting exercise and analyzed among groups using a one-way ANOVA test.
Results: Both resistance and interval training led to significant increase in insulin and beta cell function and significant decrease in glucose, serum melatonin, MTNR1A and MTNR1B expression in pancreatic tissue compared with control group (P< 0.05). Significant difference were not observed in all variables between interval and resistance groups (P> 0.05).
Conclusion: Resistance and interval training are associated with increased insulin in T2D rats, and this improvement may be attributed to decreased melatonin and its receptor expression in pancreatic beta cells. Additional research is required to elucidate alternative mechanisms that contribute to elevated insulin levels.

Keywords: Type 2 diabetes, Melatonin receptors expression, Insulin synthesis, Exercise training, Beta cell function

Full-Text [PDF 854 kb] (57 Downloads)

Type of Study: Research | Subject: Special
Received: 2025/12/2 | Accepted: 2026/05/20 | Published: 2026/06/1

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