Volume 10, Issue 4 (volume 10, number 4 2018)                   2018, 10(4): 210-215 | Back to browse issues page

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Yadegari E, Banaeifar A A, Azarbayjani M A, Arshadi S. The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats. Iranian Journal of Diabetes and Obesity 2018; 10 (4) :210-215
URL: http://ijdo.ssu.ac.ir/article-1-451-en.html
PhD, Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (2236 Views)
Objective: This study examined the effect of high intensity interval training (HIIT) on HNF-4α gene expression, glucose and insulin in liver tissue of type 2 diabetic male Wistar rats.
Materials and Methods: In this study, 20 male Wistar rats weighing 220 (±20) grams were selected. After type 2 diabetes (T2D) induction, the samples were divided into two groups of HIIT and control. The training program was 12 weeks and 5 times a week. Fasting glucose, serum insulin and HNF-4α gene expression in the liver tissue were measured in both groups after the last exercise session by using independent T-test.
Results: The results showed that HIIT decreased significantly the fasting glucose (P-value: 0.001) and increased serum insulin (P-value: 0.001). Also, the expression of HNF-4α after HIIT significantly decreased in comparison to the control group (P-value: 0.003).
Conclusion: Based on the findings, HIIT resulted in a significant decrease in fasting glucose and a significant increase in insulin that is likely to reduce the liver HNF-4α gene expression of T2D male Wistar rats by increasing serum insulin.

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Type of Study: Research | Subject: Special
Received: 2019/05/28 | Accepted: 2019/05/28 | Published: 2019/05/28

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