Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Sun, Nov 3, 2024
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Volume 12, Issue 4 (12-2020)
IJDO 2020, 12(4): 218-225 |
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Karimi M, Eizadi M. The Effect of High Intensity Intermittent Training (HIIT) on GLP-1R Expression in Pancreas Tissue and Serum Insulin of Male Wistar Rats with Type 2 Diabetes Mellitus. IJDO 2020; 12 (4) :218-225
URL: http://ijdo.ssu.ac.ir/article-1-593-en.html
URL: http://ijdo.ssu.ac.ir/article-1-593-en.html
Assistant Professor of Exercise Physiology, Qom University of Technology, Qom, Iran
Abstract: (1157 Views)
Objective: Insulin secretion and insulin resistance are associated with incidence and severity of type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of high intensity intermittent training (HIIT) on GLP-1R expression in pancreas tissue and serum insulin of T2DM rats.
Materials and Methods: In this quasi-experimental study, T2DM induced by intraperitoneal injection of streptozotocin-Nicotinamide in 16 male wistar rats aged 10 weeks (220 – 20 g). The rats were divided into control (no-training, n= 8) and HIIT (5 times/ week/12-week, n= 8) groups. GLP-1R expression in pancreas tissue, fasting glucose and serum insulin were measured 48 h after lasted exercise of exercise and control groups. Independent and paired T-test was used to compare variables between 2 groups.
Results: HIIT resulted in significant increase in GLP-1R expression compared to control subjects (P-value: 0.023). Fasting glucose decreased (P-value< 0.0001) and serum insulin increased (P-value< 0.0001) in response to HIIT when compared to control subjects.
Conclusion: HIIT can improve insulin secretion in male rats with T2DM and this improvement can be attributed to increased GLP-1R expression in pancreas tissue in response to training protocol.
Materials and Methods: In this quasi-experimental study, T2DM induced by intraperitoneal injection of streptozotocin-Nicotinamide in 16 male wistar rats aged 10 weeks (220 – 20 g). The rats were divided into control (no-training, n= 8) and HIIT (5 times/ week/12-week, n= 8) groups. GLP-1R expression in pancreas tissue, fasting glucose and serum insulin were measured 48 h after lasted exercise of exercise and control groups. Independent and paired T-test was used to compare variables between 2 groups.
Results: HIIT resulted in significant increase in GLP-1R expression compared to control subjects (P-value: 0.023). Fasting glucose decreased (P-value< 0.0001) and serum insulin increased (P-value< 0.0001) in response to HIIT when compared to control subjects.
Conclusion: HIIT can improve insulin secretion in male rats with T2DM and this improvement can be attributed to increased GLP-1R expression in pancreas tissue in response to training protocol.
Type of Study: Research |
Subject:
Special
Received: 2021/01/12 | Accepted: 2020/12/20 | Published: 2020/12/20
Received: 2021/01/12 | Accepted: 2020/12/20 | Published: 2020/12/20
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